KEGG   ORTHOLOGY: K19180
Entry
K19180                      KO                                     

Name
tll
Definition
dTDP-6-deoxy-L-talose 4-dehydrogenase (NAD+) [EC:1.1.1.339]
Pathway
ko00523  Polyketide sugar unit biosynthesis
ko00541  O-Antigen nucleotide sugar biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00541 O-Antigen nucleotide sugar biosynthesis
    K19180  tll; dTDP-6-deoxy-L-talose 4-dehydrogenase (NAD+)
  09109 Metabolism of terpenoids and polyketides
   00523 Polyketide sugar unit biosynthesis
    K19180  tll; dTDP-6-deoxy-L-talose 4-dehydrogenase (NAD+)
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.339  dTDP-6-deoxy-L-talose 4-dehydrogenase (NAD+)
     K19180  tll; dTDP-6-deoxy-L-talose 4-dehydrogenase (NAD+)
Other DBs
RN: R10190
COG: COG0451
Genes
AAT: D11S_1703
AG: BAA28138(tll)
Reference
  Authors
Nakano Y, Suzuki N, Yoshida Y, Nezu T, Yamashita Y, Koga T
  Title
Thymidine diphosphate-6-deoxy-L-lyxo-4-hexulose reductase synthesizing dTDP-6-deoxy-L-talose from Actinobacillus actinomycetemcomitans.
  Journal
J Biol Chem 275:6806-12 (2000)
DOI:10.1074/jbc.275.10.6806
  Sequence

KEGG   ENZYME: 1.1.1.339
Entry
EC 1.1.1.339                Enzyme                                 

Name
dTDP-6-deoxy-L-talose 4-dehydrogenase (NAD+);
tll (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
dTDP-6-deoxy-beta-L-talose:NAD+ 4-oxidoreductase
Reaction(IUBMB)
dTDP-6-deoxy-beta-L-talose + NAD+ = dTDP-4-dehydro-beta-L-rhamnose + NADH + H+ [RN:R10190]
Reaction(KEGG)
R10190
Substrate
dTDP-6-deoxy-beta-L-talose [CPD:C03187];
NAD+ [CPD:C00003]
Product
dTDP-4-dehydro-beta-L-rhamnose [CPD:C00688];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme has been characterized from the bacterium Aggregatibacter actinomycetemcomitans, in which it participates in the biosynthesis of the serotype c-specific polysaccharide antigen. Shows no activity with NADP+.
History
EC 1.1.1.339 created 2012
Pathway
ec00523  Polyketide sugar unit biosynthesis
ec00541  O-Antigen nucleotide sugar biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K19180  dTDP-6-deoxy-L-talose 4-dehydrogenase (NAD+)
Genes
AAT: D11S_1703
Reference
1  [PMID:10702238]
  Authors
Nakano Y, Suzuki N, Yoshida Y, Nezu T, Yamashita Y, Koga T
  Title
Thymidine diphosphate-6-deoxy-L-lyxo-4-hexulose reductase synthesizing dTDP-6-deoxy-L-talose from Actinobacillus actinomycetemcomitans.
  Journal
J Biol Chem 275:6806-12 (2000)
DOI:10.1074/jbc.275.10.6806
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.339
IUBMB Enzyme Nomenclature: 1.1.1.339
ExPASy - ENZYME nomenclature database: 1.1.1.339
BRENDA, the Enzyme Database: 1.1.1.339

KEGG   REACTION: R10190
Entry
R10190                      Reaction                               

Name
dTDP-6-deoxy-beta-L-talose:NAD+ 4-oxidoreductase
Definition
dTDP-6-deoxy-beta-L-talose + NAD+ <=> dTDP-4-dehydro-beta-L-rhamnose + NADH + H+
Equation
Comment
NADP+ (see R02776)
Reaction class
RC00001  C00003_C00004
RC00182  C00688_C03187
Enzyme
1.1.1.339       1.1.1.344
Pathway
rn00523  Polyketide sugar unit biosynthesis
rn00541  O-Antigen nucleotide sugar biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K19180  dTDP-6-deoxy-L-talose 4-dehydrogenase (NAD+) [EC:1.1.1.339]
K19652  dTDP-6-deoxy-L-talose 4-dehydrogenase [NAD(P)+] [EC:1.1.1.344]
Other DBs
RHEA: 34450

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