KEGG   ORTHOLOGY: K19650
Entry
K19650            Tight     KO                                     
Symbol
SDH
Name
secoisolariciresinol dehydrogenase [EC:1.1.1.331]
Pathway
map00999  Biosynthesis of various plant secondary metabolites
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00902  Podophyllotoxin biosynthesis, coniferyl alcohol => podophyllotoxin
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00999 Biosynthesis of various plant secondary metabolites
    K19650  SDH; secoisolariciresinol dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.331  secoisolariciresinol dehydrogenase
     K19650  SDH; secoisolariciresinol dehydrogenase
Other DBs
RN: R10129
Genes
AG: AAK38664(SDH) ABN14311(SDH)
Reference
  Authors
Xia ZQ, Costa MA, Pelissier HC, Davin LB, Lewis NG
  Title
Secoisolariciresinol dehydrogenase purification, cloning, and functional expression. Implications for human health protection.
  Journal
J Biol Chem 276:12614-23 (2001)
DOI:10.1074/jbc.M008622200
  Sequence
Reference
  Authors
Lau W, Sattely ES
  Title
Six enzymes from mayapple that complete the biosynthetic pathway to the etoposide aglycone.
  Journal
Science 349:1224-8 (2015)
DOI:10.1126/science.aac7202
  Sequence

KEGG   ENZYME: 1.1.1.331
Entry
EC 1.1.1.331                Enzyme                                 
Name
secoisolariciresinol dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(-)-secoisolariciresinol:NAD+ oxidoreductase
Reaction(IUBMB)
(-)-secoisolariciresinol + 2 NAD+ = (-)-matairesinol + 2 NADH + 2 H+ [RN:R10129]
Reaction(KEGG)
R10129
Substrate
(-)-secoisolariciresinol [CPD:C18167];
NAD+ [CPD:C00003]
Product
(-)-matairesinol [CPD:C10682];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Isolated from the plants Forsythia intermedia [1] and Podophyllum peltatum [1-3]. An intermediate lactol is detected in vitro.
History
EC 1.1.1.331 created 2012
Pathway
ec00999  Biosynthesis of various plant secondary metabolites
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K19650  secoisolariciresinol dehydrogenase
Reference
1  [PMID:11278426]
  Authors
Xia ZQ, Costa MA, Pelissier HC, Davin LB, Lewis NG
  Title
Secoisolariciresinol dehydrogenase purification, cloning, and functional expression. Implications for human health protection.
  Journal
J Biol Chem 276:12614-23 (2001)
DOI:10.1074/jbc.M008622200
  Sequence
Reference
2  [PMID:15653677]
  Authors
Youn B, Moinuddin SG, Davin LB, Lewis NG, Kang C
  Title
Crystal structures of apo-form and binary/ternary complexes of Podophyllum secoisolariciresinol dehydrogenase, an enzyme involved in formation of health-protecting and plant defense lignans.
  Journal
J Biol Chem 280:12917-26 (2005)
DOI:10.1074/jbc.M413266200
  Sequence
Reference
3  [PMID:16493463]
  Authors
Moinuddin SG, Youn B, Bedgar DL, Costa MA, Helms GL, Kang C, Davin LB, Lewis NG
  Title
Secoisolariciresinol dehydrogenase: mode of catalysis and stereospecificity of hydride transfer in Podophyllum peltatum.
  Journal
Org Biomol Chem 4:808-16 (2006)
DOI:10.1039/b516563f
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.331
IUBMB Enzyme Nomenclature: 1.1.1.331
ExPASy - ENZYME nomenclature database: 1.1.1.331
BRENDA, the Enzyme Database: 1.1.1.331

KEGG   REACTION: R10129
Entry
R10129                      Reaction                               
Name
(-)-secoisolariciresinol:NAD+ oxidoreductase
Definition
Secoisolariciresinol + 2 NAD+ <=> Matairesinol + 2 NADH + 2 H+
Equation
C18167 + 2 C00003 <=> C10682 + 2 C00004 + 2 C00080
Comment
multi-step reaction
intermediate (cyclic hemiacetal)
Reaction class
RC00001  C00003_C00004
RC03052  C10682_C18167
Enzyme
Pathway
rn00999  Biosynthesis of various plant secondary metabolites
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00902  Podophyllotoxin biosynthesis, coniferyl alcohol => podophyllotoxin
Orthology
K19650  secoisolariciresinol dehydrogenase [EC:1.1.1.331]
Other DBs
RHEA: 33890

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