KEGG   ORTHOLOGY: K19652
Entry
K19652            Tight     KO                                     

Name
tal
Definition
dTDP-6-deoxy-L-talose 4-dehydrogenase [NAD(P)+] [EC:1.1.1.344]
Pathway
ko00523  Polyketide sugar unit biosynthesis
ko00541  O-Antigen nucleotide sugar biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00541 O-Antigen nucleotide sugar biosynthesis
    K19652  tal; dTDP-6-deoxy-L-talose 4-dehydrogenase [NAD(P)+]
  09109 Metabolism of terpenoids and polyketides
   00523 Polyketide sugar unit biosynthesis
    K19652  tal; dTDP-6-deoxy-L-talose 4-dehydrogenase [NAD(P)+]
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.344  dTDP-6-deoxy-L-talose 4-dehydrogenase [NAD(P)+]
     K19652  tal; dTDP-6-deoxy-L-talose 4-dehydrogenase [NAD(P)+]
Other DBs
RN: R02776 R10190
Genes
AG: ADO32602(tal)
Reference
  Authors
Karki S, Yoo HG, Kwon SY, Suh JW, Kwon HJ
  Title
Cloning and in vitro characterization of dTDP-6-deoxy-L-talose biosynthetic genes from Kitasatospora kifunensis featuring the dTDP-6-deoxy-L-lyxo-4-hexulose reductase that synthesizes dTDP-6-deoxy-L-talose.
  Journal
Carbohydr Res 345:1958-62 (2010)
DOI:10.1016/j.carres.2010.07.004
  Sequence

KEGG   ENZYME: 1.1.1.344
Entry
EC 1.1.1.344                Enzyme                                 

Name
dTDP-6-deoxy-L-talose 4-dehydrogenase [NAD(P)+];
tal (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
dTDP-6-deoxy-beta-L-talose:NAD(P)+ 4-oxidoreductase
Reaction(IUBMB)
dTDP-6-deoxy-beta-L-talose + NAD(P)+ = dTDP-4-dehydro-beta-L-rhamnose + NAD(P)H + H+ [RN:R02776 R10190]
Reaction(KEGG)
R02776 R10190
Substrate
dTDP-6-deoxy-beta-L-talose [CPD:C03187];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
dTDP-4-dehydro-beta-L-rhamnose [CPD:C00688];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme works equally well with NAD+ and NADP+.
History
EC 1.1.1.344 created 2013
Pathway
ec00523  Polyketide sugar unit biosynthesis
ec00541  O-Antigen nucleotide sugar biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K19652  dTDP-6-deoxy-L-talose 4-dehydrogenase [NAD(P)+]
Reference
1  [PMID:20667525]
  Authors
Karki S, Yoo HG, Kwon SY, Suh JW, Kwon HJ
  Title
Cloning and in vitro characterization of dTDP-6-deoxy-L-talose biosynthetic genes from Kitasatospora kifunensis featuring the dTDP-6-deoxy-L-lyxo-4-hexulose reductase that synthesizes dTDP-6-deoxy-L-talose.
  Journal
Carbohydr Res 345:1958-62 (2010)
DOI:10.1016/j.carres.2010.07.004
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.344
IUBMB Enzyme Nomenclature: 1.1.1.344
ExPASy - ENZYME nomenclature database: 1.1.1.344
BRENDA, the Enzyme Database: 1.1.1.344

KEGG   REACTION: R02776
Entry
R02776                      Reaction                               

Name
dTDP-6-deoxy-L-talose:NADP+ 4-oxidoreductase
Definition
dTDP-6-deoxy-beta-L-talose + NADP+ <=> dTDP-4-dehydro-beta-L-rhamnose + NADPH + H+
Equation
Comment
NAD+ (see R10190)
Reaction class
RC00001  C00005_C00006
RC00182  C00688_C03187
Enzyme
1.1.1.134       1.1.1.344
Pathway
rn00523  Polyketide sugar unit biosynthesis
rn00541  O-Antigen nucleotide sugar biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K19652  dTDP-6-deoxy-L-talose 4-dehydrogenase [NAD(P)+] [EC:1.1.1.344]
Other DBs
RHEA: 23651

KEGG   REACTION: R10190
Entry
R10190                      Reaction                               

Name
dTDP-6-deoxy-beta-L-talose:NAD+ 4-oxidoreductase
Definition
dTDP-6-deoxy-beta-L-talose + NAD+ <=> dTDP-4-dehydro-beta-L-rhamnose + NADH + H+
Equation
Comment
NADP+ (see R02776)
Reaction class
RC00001  C00003_C00004
RC00182  C00688_C03187
Enzyme
1.1.1.339       1.1.1.344
Pathway
rn00523  Polyketide sugar unit biosynthesis
rn00541  O-Antigen nucleotide sugar biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K19180  dTDP-6-deoxy-L-talose 4-dehydrogenase (NAD+) [EC:1.1.1.339]
K19652  dTDP-6-deoxy-L-talose 4-dehydrogenase [NAD(P)+] [EC:1.1.1.344]
Other DBs
RHEA: 34450

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