KEGG   ORTHOLOGY: K19653
Entry
K19653                      KO                                     

Symbol
geoA
Name
geraniol dehydrogenase (NAD+) [EC:1.1.1.347]
Pathway
map00281  Geraniol degradation
map01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00281 Geraniol degradation
    K19653  geoA; geraniol dehydrogenase (NAD+)
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.347  geraniol dehydrogenase (NAD+)
     K19653  geoA; geraniol dehydrogenase (NAD+)
Other DBs
RN: R10308
Genes
CDN: BN940_14111
AG: CCF55024(geoA)
Reference
  Authors
Luddeke F, Wulfing A, Timke M, Germer F, Weber J, Dikfidan A, Rahnfeld T, Linder D, Meyerdierks A, Harder J
  Title
Geraniol and geranial dehydrogenases induced in anaerobic monoterpene degradation by Castellaniella defragrans.
  Journal
Appl Environ Microbiol 78:2128-36 (2012)
DOI:10.1128/AEM.07226-11
  Sequence

KEGG   ENZYME: 1.1.1.347
Entry
EC 1.1.1.347                Enzyme                                 

Name
geraniol dehydrogenase (NAD+);
GeDH;
geoA (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
geraniol:NAD+ oxidoreductase
Reaction(IUBMB)
geraniol + NAD+ = geranial + NADH + H+ [RN:R10308]
Reaction(KEGG)
R10308
Substrate
geraniol [CPD:C01500];
NAD+ [CPD:C00003]
Product
geranial [CPD:C01499];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme from the bacterium Castellaniella defragrans is most active in vitro with perillyl alcohol [2]. The enzyme from the prune mite Carpoglyphus lactis also acts (more slowly) on farnesol but not on nerol [1].
History
EC 1.1.1.347 created 2013
Pathway
ec00281  Geraniol degradation
ec01110  Biosynthesis of secondary metabolites
Orthology
K19653  geraniol dehydrogenase (NAD+)
Genes
CDN: BN940_14111
Reference
1  [PMID:18422649]
  Authors
Noge K, Kato M, Mori N, Kataoka M, Tanaka C, Yamasue Y, Nishida R, Kuwahara Y
  Title
Geraniol dehydrogenase, the key enzyme in biosynthesis of the alarm pheromone, from the astigmatid mite Carpoglyphus lactis (Acari: Carpoglyphidae).
  Journal
FEBS J 275:2807-17 (2008)
DOI:10.1111/j.1742-4658.2008.06421.x
Reference
2  [PMID:22286981]
  Authors
Luddeke F, Wulfing A, Timke M, Germer F, Weber J, Dikfidan A, Rahnfeld T, Linder D, Meyerdierks A, Harder J
  Title
Geraniol and geranial dehydrogenases induced in anaerobic monoterpene degradation by Castellaniella defragrans.
  Journal
Appl Environ Microbiol 78:2128-36 (2012)
DOI:10.1128/AEM.07226-11
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.347
IUBMB Enzyme Nomenclature: 1.1.1.347
ExPASy - ENZYME nomenclature database: 1.1.1.347
BRENDA, the Enzyme Database: 1.1.1.347

KEGG   REACTION: R10308
Entry
R10308                      Reaction                               

Name
geraniol:NAD+ oxidoreductase
Definition
Geraniol + NAD+ <=> Geranial + NADH + H+
Equation
Comment
NADP+ (ec 1.1.1.183, see R03581)
Reaction class
RC00001  C00003_C00004
RC00649  C01499_C01500
Enzyme
Pathway
rn00281  Geraniol degradation
rn01110  Biosynthesis of secondary metabolites
Orthology
K19653  geraniol dehydrogenase (NAD+) [EC:1.1.1.347]
Other DBs
RHEA: 34350

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