KEGG ORTHOLOGY: K19699

ORTHOLOGY: K19699

Entry

K19699            Tight     KO

Symbol

safD

Name

sulfoacetaldehyde dehydrogenase [EC:1.2.1.73]

Pathway

map00430

Taurine and hypotaurine metabolism

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09106 Metabolism of other amino acids
   00430 Taurine and hypotaurine metabolism
    K19699  safD; sulfoacetaldehyde dehydrogenase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.1  With NAD+ or NADP+ as acceptor
    1.2.1.73  sulfoacetaldehyde dehydrogenase
     K19699  safD; sulfoacetaldehyde dehydrogenase

Other DBs

RN:

R06980

Genes

AG:	EAR61922(safD)

Reference

PMID:18506422

Authors

Krejcik Z, Denger K, Weinitschke S, Hollemeyer K, Paces V, Cook AM, Smits TH

Title

Sulfoacetate released during the assimilation of taurine-nitrogen by Neptuniibacter caesariensis: purification of sulfoacetaldehyde dehydrogenase.

Journal

Arch Microbiol 190:159-68 (2008)
DOI:10.1007/s00203-008-0386-2

Sequence

[ag:EAR61922]

All links

Ontology (2)   
   KEGG BRITE (2)   
Pathway (2)   
   KEGG PATHWAY (2)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (1)   
   KEGG GENES (1)   
Literature (1)   
   PubMed (1)   
All databases (9)   

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ENZYME: 1.2.1.73

Entry

EC 1.2.1.73                 Enzyme

Name

sulfoacetaldehyde dehydrogenase;
SafD

Class

Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor

Sysname

2-sulfoacetaldehyde:NAD+ oxidoreductase

Reaction(IUBMB)

2-sulfoacetaldehyde + H2O + NAD+ = sulfoacetate + NADH + 2 H+ [RN:R06980]

Reaction(KEGG)

R06980

Substrate

2-sulfoacetaldehyde [CPD:C00593];
H2O [CPD:C00001];
NAD+ [CPD:C00003]

Product

sulfoacetate [CPD:C14179];
NADH [CPD:C00004];
H+ [CPD:C00080]

Comment

This reaction is part of a bacterial pathway that can utilize the amino group of taurine as a sole source of nitrogen for growth. At physiological concentrations, NAD+ cannot be replaced by NADP+. The enzyme is specific for sulfoacetaldehyde, as formaldehyde, acetaldehyde, betaine aldehyde, propanal, glyceraldehyde, phosphonoacetaldehyde, glyoxylate, glycolaldehyde and 2-oxobutyrate are not substrates.

History

EC 1.2.1.73 created 2008

Pathway

ec00430

Taurine and hypotaurine metabolism

Orthology

K19699

sulfoacetaldehyde dehydrogenase

Reference

1 [PMID:18506422]

Authors

Krejcik Z, Denger K, Weinitschke S, Hollemeyer K, Paces V, Cook AM, Smits TH

Title

Sulfoacetate released during the assimilation of taurine-nitrogen by Neptuniibacter caesariensis: purification of sulfoacetaldehyde dehydrogenase.

Journal

Arch Microbiol 190:159-68 (2008)
DOI:10.1007/s00203-008-0386-2

Sequence

[ag:EAR61922]

Other DBs

ExplorEnz - The Enzyme Database:

1.2.1.73

IUBMB Enzyme Nomenclature:

1.2.1.73

ExPASy - ENZYME nomenclature database:

1.2.1.73

BRENDA, the Enzyme Database:

1.2.1.73

REACTION: R06980

Entry

R06980                      Reaction

Name

sulfoacetaldehyde:NAD+ oxidoreductase

Definition

Sulfoacetaldehyde + NAD+ + H2O <=> Sulfoacetate + NADH + H+

Equation

C00593 + C00003 + C00001 <=> C14179 + C00004 + C00080

Reaction class

RC00001

C00003_C00004

RC00080

C00593_C14179

Enzyme

1.2.1.73

Pathway

rn00430

Taurine and hypotaurine metabolism

Orthology

K19699

sulfoacetaldehyde dehydrogenase [EC:1.2.1.73]

Other DBs

RHEA:

25640

All links

Ontology (1)   
   KEGG BRITE (1)   
Pathway (2)   
   KEGG PATHWAY (2)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG RCLASS (2)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
All databases (14)   

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