KEGG   ORTHOLOGY: K19699
Entry
K19699            Tight     KO                                     
Symbol
safD
Name
sulfoacetaldehyde dehydrogenase [EC:1.2.1.73]
Pathway
map00430  Taurine and hypotaurine metabolism
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00430 Taurine and hypotaurine metabolism
    K19699  safD; sulfoacetaldehyde dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.1  With NAD+ or NADP+ as acceptor
    1.2.1.73  sulfoacetaldehyde dehydrogenase
     K19699  safD; sulfoacetaldehyde dehydrogenase
Other DBs
RN: R06980
Genes
AG: EAR61922(safD)
Reference
  Authors
Krejcik Z, Denger K, Weinitschke S, Hollemeyer K, Paces V, Cook AM, Smits TH
  Title
Sulfoacetate released during the assimilation of taurine-nitrogen by Neptuniibacter caesariensis: purification of sulfoacetaldehyde dehydrogenase.
  Journal
Arch Microbiol 190:159-68 (2008)
DOI:10.1007/s00203-008-0386-2
  Sequence

KEGG   ENZYME: 1.2.1.73
Entry
EC 1.2.1.73                 Enzyme                                 
Name
sulfoacetaldehyde dehydrogenase;
SafD
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
Sysname
2-sulfoacetaldehyde:NAD+ oxidoreductase
Reaction(IUBMB)
2-sulfoacetaldehyde + H2O + NAD+ = sulfoacetate + NADH + 2 H+ [RN:R06980]
Reaction(KEGG)
R06980
Substrate
2-sulfoacetaldehyde [CPD:C00593];
H2O [CPD:C00001];
NAD+ [CPD:C00003]
Product
sulfoacetate [CPD:C14179];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
This reaction is part of a bacterial pathway that can utilize the amino group of taurine as a sole source of nitrogen for growth. At physiological concentrations, NAD+ cannot be replaced by NADP+. The enzyme is specific for sulfoacetaldehyde, as formaldehyde, acetaldehyde, betaine aldehyde, propanal, glyceraldehyde, phosphonoacetaldehyde, glyoxylate, glycolaldehyde and 2-oxobutyrate are not substrates.
History
EC 1.2.1.73 created 2008
Pathway
ec00430  Taurine and hypotaurine metabolism
Orthology
K19699  sulfoacetaldehyde dehydrogenase
Reference
1  [PMID:18506422]
  Authors
Krejcik Z, Denger K, Weinitschke S, Hollemeyer K, Paces V, Cook AM, Smits TH
  Title
Sulfoacetate released during the assimilation of taurine-nitrogen by Neptuniibacter caesariensis: purification of sulfoacetaldehyde dehydrogenase.
  Journal
Arch Microbiol 190:159-68 (2008)
DOI:10.1007/s00203-008-0386-2
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.73
IUBMB Enzyme Nomenclature: 1.2.1.73
ExPASy - ENZYME nomenclature database: 1.2.1.73
BRENDA, the Enzyme Database: 1.2.1.73

KEGG   REACTION: R06980
Entry
R06980                      Reaction                               
Name
sulfoacetaldehyde:NAD+ oxidoreductase
Definition
Sulfoacetaldehyde + NAD+ + H2O <=> Sulfoacetate + NADH + H+
Equation
Reaction class
RC00001  C00003_C00004
RC00080  C00593_C14179
Enzyme
Pathway
rn00430  Taurine and hypotaurine metabolism
Orthology
K19699  sulfoacetaldehyde dehydrogenase [EC:1.2.1.73]
Other DBs
RHEA: 25640

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