KEGG   ORTHOLOGY: K19960
Entry
K19960            Tight     KO                                     
Symbol
chnA
Name
cyclohexanol dehydrogenase [EC:1.1.1.245]
Pathway
map00930  Caprolactam degradation
map01220  Degradation of aromatic compounds
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00930 Caprolactam degradation
    K19960  chnA; cyclohexanol dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.245  cyclohexanol dehydrogenase
     K19960  chnA; cyclohexanol dehydrogenase
Other DBs
RN: R02229
COG: COG1028
GO: 0018460
Genes
AG: BAC80215(chnA)
Reference
  Authors
Iwaki H, Hasegawa Y, Teraoka M, Tokuyama T, Bergeron H, Lau PC
  Title
Identification of a transcriptional activator (ChnR) and a 6-oxohexanoate dehydrogenase (ChnE) in the cyclohexanol catabolic pathway in Acinetobacter sp. Strain NCIMB 9871 and localization of the genes that encode them.
  Journal
Appl Environ Microbiol 65:5158-62 (1999)
DOI:10.1128/AEM.65.11.5158-5162.1999
  Sequence

KEGG   ENZYME: 1.1.1.245
Entry
EC 1.1.1.245                Enzyme                                 
Name
cyclohexanol dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
cyclohexanol:NAD+ oxidoreductase
Reaction(IUBMB)
cyclohexanol + NAD+ = cyclohexanone + NADH + H+ [RN:R02229]
Reaction(KEGG)
R02229
Substrate
cyclohexanol [CPD:C00854];
NAD+ [CPD:C00003]
Product
cyclohexanone [CPD:C00414];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Also oxidizes some other alicyclic alcohols and diols.
History
EC 1.1.1.245 created 1992
Pathway
ec00930  Caprolactam degradation
ec01120  Microbial metabolism in diverse environments
Orthology
K19960  cyclohexanol dehydrogenase
Reference
1  [PMID:2505723]
  Authors
Dangel W, Tschech A, Fuchs G
  Title
Enzyme reactions involved in anaerobic cyclohexanol metabolism by a denitrifying  Pseudomonas species.
  Journal
Arch Microbiol 152:271-9 (1989)
DOI:10.1007/bf00409663
Reference
2  [PMID:1261]
  Authors
Donoghue NA, Trudgill PW.
  Title
The metabolism of cyclohexanol by Acinetobacter NCIB 9871.
  Journal
Eur J Biochem 60:1-7 (1975)
DOI:10.1111/j.1432-1033.1975.tb20968.x
Reference
3  [PMID:16346796]
  Authors
Trower MK, Buckland RM, Higgins R, Griffin M.
  Title
Isolation and Characterization of a Cyclohexane-Metabolizing Xanthobacter sp.
  Journal
Appl Environ Microbiol 49:1282-1289 (1985)
DOI:10.1128/AEM.49.5.1282-1289.1985
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.245
IUBMB Enzyme Nomenclature: 1.1.1.245
ExPASy - ENZYME nomenclature database: 1.1.1.245
UM-BBD (Biocatalysis/Biodegradation Database): 1.1.1.245
BRENDA, the Enzyme Database: 1.1.1.245
CAS: 63951-98-4

KEGG   REACTION: R02229
Entry
R02229                      Reaction                               
Name
cyclohexanol:NAD+ oxidoreductase
Definition
Cyclohexanone + NADH + H+ <=> Cyclohexanol + NAD+
Equation
Reaction class
RC00001  C00003_C00004
RC00144  C00414_C00854
Enzyme
1.1.1.163       1.1.1.245
Pathway
rn00930  Caprolactam degradation
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
Orthology
K17754  cyclopentanol dehydrogenase [EC:1.1.1.163]
K19960  cyclohexanol dehydrogenase [EC:1.1.1.245]
Other DBs
RHEA: 10047

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