KEGG   ORTHOLOGY: K19961
Entry
K19961                      KO                                     
Symbol
chnD
Name
6-hydroxyhexanoate dehydrogenase [EC:1.1.1.258]
Pathway
map00930  Caprolactam degradation
map01220  Degradation of aromatic compounds
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00930 Caprolactam degradation
    K19961  chnD; 6-hydroxyhexanoate dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.258  6-hydroxyhexanoate dehydrogenase
     K19961  chnD; 6-hydroxyhexanoate dehydrogenase
Other DBs
RN: R05283
COG: COG1064
GO: 0018463
Genes
PPJ: RK21_02869
CUU: BKK79_21280
AJS: Ajs_2098
AVQ: HRR99_17355
AG: BAC80217(chnD)
Reference
  Authors
Iwaki H, Hasegawa Y, Teraoka M, Tokuyama T, Bergeron H, Lau PC
  Title
Identification of a transcriptional activator (ChnR) and a 6-oxohexanoate dehydrogenase (ChnE) in the cyclohexanol catabolic pathway in Acinetobacter sp. Strain NCIMB 9871 and localization of the genes that encode them.
  Journal
Appl Environ Microbiol 65:5158-62 (1999)
DOI:10.1128/AEM.65.11.5158-5162.1999
  Sequence

KEGG   ENZYME: 1.1.1.258
Entry
EC 1.1.1.258                Enzyme                                 
Name
6-hydroxyhexanoate dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
6-hydroxyhexanoate:NAD+ oxidoreductase
Reaction(IUBMB)
6-hydroxyhexanoate + NAD+ = 6-oxohexanoate + NADH + H+ [RN:R05283]
Reaction(KEGG)
R05283
Substrate
6-hydroxyhexanoate [CPD:C06103];
NAD+ [CPD:C00003]
Product
6-oxohexanoate [CPD:C06102];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Involved in the cyclohexanol degradation pathway in Acinetobacter NCIB 9871.
History
EC 1.1.1.258 created 2000
Pathway
ec00930  Caprolactam degradation
ec01120  Microbial metabolism in diverse environments
Orthology
K19961  6-hydroxyhexanoate dehydrogenase
Genes
PPJRK21_02869
CUUBKK79_21280
AJSAjs_2098
AVQHRR99_17355
Reference
1  [PMID:1261]
  Authors
Donoghue NA, Trudgill PW.
  Title
The metabolism of cyclohexanol by Acinetobacter NCIB 9871.
  Journal
Eur J Biochem 60:1-7 (1975)
DOI:10.1111/j.1432-1033.1975.tb20968.x
Reference
2  [PMID:6722936]
  Authors
Hecker LI, Tondeur Y, Farrelly JG.
  Title
Formation of epsilon-hydroxycaproate and epsilon-aminocaproate from N-nitrosohexamethyleneimine: evidence that microsomal alpha-hydroxylation of cyclic nitrosamines may not always involve the insertion of molecular oxygen into the substrate.
  Journal
Chem Biol Interact 49:235-48 (1984)
DOI:10.1016/0009-2797(84)90064-4
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.258
IUBMB Enzyme Nomenclature: 1.1.1.258
ExPASy - ENZYME nomenclature database: 1.1.1.258
UM-BBD (Biocatalysis/Biodegradation Database): 1.1.1.258
BRENDA, the Enzyme Database: 1.1.1.258
CAS: 77000-03-4

KEGG   REACTION: R05283
Entry
R05283                      Reaction                               
Name
6-hydroxyhexanoate:NAD+ oxidoreductase
Definition
6-Hydroxyhexanoic acid + NAD+ <=> Adipate semialdehyde + NADH + H+
Equation
Reaction class
RC00001  C00003_C00004
RC00087  C06102_C06103
Enzyme
Pathway
rn00930  Caprolactam degradation
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
Orthology
K19961  6-hydroxyhexanoate dehydrogenase [EC:1.1.1.258]
Other DBs
RHEA: 14228

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