KEGG ORTHOLOGY: K19961

ORTHOLOGY: K19961

Entry

K19961                      KO

Symbol

chnD

Name

6-hydroxyhexanoate dehydrogenase [EC:1.1.1.258]

Pathway

map00930

Caprolactam degradation

map01220

Degradation of aromatic compounds

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00930 Caprolactam degradation
    K19961  chnD; 6-hydroxyhexanoate dehydrogenase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.258  6-hydroxyhexanoate dehydrogenase
     K19961  chnD; 6-hydroxyhexanoate dehydrogenase

Other DBs

RN:

R05283

COG:

COG1064

GO:

0018463

Genes

PPJ:	RK21_02869

CUU:	BKK79_21280

AALN:

Q3V95_06285

AJS:

Ajs_2098

ATEM:

PQV96_11860

HCZ:	G9Q37_07270

AVQ:	HRR99_17355

RTU:	PR017_22970

NPM:	QEO92_27350

NACI:

NUH88_20725

RPSK:

JWS13_42125

AG:	BAC80217(chnD)

» show all

Reference

PMID:10543838

Authors

Iwaki H, Hasegawa Y, Teraoka M, Tokuyama T, Bergeron H, Lau PC

Title

Identification of a transcriptional activator (ChnR) and a 6-oxohexanoate dehydrogenase (ChnE) in the cyclohexanol catabolic pathway in Acinetobacter sp. Strain NCIMB 9871 and localization of the genes that encode them.

Journal

Appl Environ Microbiol 65:5158-62 (1999)
DOI:10.1128/AEM.65.11.5158-5162.1999

Sequence

[ag:BAC80217]

All links

Ontology (4)   
   KEGG BRITE (2)   
   GO (1)   
   COG (1)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (13)   
   KEGG GENES (12)   
   OC (1)   
Literature (1)   
   PubMed (1)   
All databases (25)   

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ENZYME: 1.1.1.258

Entry

EC 1.1.1.258                Enzyme

Name

6-hydroxyhexanoate dehydrogenase

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

6-hydroxyhexanoate:NAD+ oxidoreductase

Reaction(IUBMB)

6-hydroxyhexanoate + NAD+ = 6-oxohexanoate + NADH + H+ [RN:R05283]

Reaction(KEGG)

R05283

Substrate

6-hydroxyhexanoate [CPD:C06103];
NAD+ [CPD:C00003]

Product

6-oxohexanoate [CPD:C06102];
NADH [CPD:C00004];
H+ [CPD:C00080]

Comment

Involved in the cyclohexanol degradation pathway in Acinetobacter NCIB 9871.

History

EC 1.1.1.258 created 2000

Pathway

ec00930

Caprolactam degradation

ec01120

Microbial metabolism in diverse environments

Orthology

K19961

6-hydroxyhexanoate dehydrogenase

Genes

PPJ:	RK21_02869

CUU:	BKK79_21280

AALN:

Q3V95_06285

AJS:

Ajs_2098

ATEM:

PQV96_11860

HCZ:	G9Q37_07270

AVQ:	HRR99_17355

RTU:	PR017_22970

NPM:	QEO92_27350

NACI:

NUH88_20725

RPSK:

JWS13_42125

» show all

Reference

1 [PMID:1261]

Authors

Donoghue NA, Trudgill PW.

Title

The metabolism of cyclohexanol by Acinetobacter NCIB 9871.

Journal

Eur J Biochem 60:1-7 (1975)
DOI:10.1111/j.1432-1033.1975.tb20968.x

Reference

2 [PMID:6722936]

Authors

Hecker LI, Tondeur Y, Farrelly JG.

Title

Formation of epsilon-hydroxycaproate and epsilon-aminocaproate from N-nitrosohexamethyleneimine: evidence that microsomal alpha-hydroxylation of cyclic nitrosamines may not always involve the insertion of molecular oxygen into the substrate.

Journal

Chem Biol Interact 49:235-48 (1984)
DOI:10.1016/0009-2797(84)90064-4

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.258

IUBMB Enzyme Nomenclature:

1.1.1.258

ExPASy - ENZYME nomenclature database:

1.1.1.258

UM-BBD (Biocatalysis/Biodegradation Database):

1.1.1.258

BRENDA, the Enzyme Database:

1.1.1.258

CAS:	77000-03-4

All links

Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (13)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (12)   
Protein sequence (2)   
   UniProt (2)   
DNA sequence (4)   
   GenBank (2)   
   EMBL (2)   
Enzyme (1)   
   UMBBD-EC (1)   
All databases (31)   

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REACTION: R05283

Entry

R05283                      Reaction

Name

6-hydroxyhexanoate:NAD+ oxidoreductase

Definition

6-Hydroxyhexanoic acid + NAD+ <=> Adipate semialdehyde + NADH + H+

Equation

C06103 + C00003 <=> C06102 + C00004 + C00080

Reaction class

RC00001

C00003_C00004

RC00087

C06102_C06103

Enzyme

1.1.1.258

Pathway

rn00930

Caprolactam degradation

rn01120

Microbial metabolism in diverse environments

rn01220

Degradation of aromatic compounds

Orthology

K19961

6-hydroxyhexanoate dehydrogenase [EC:1.1.1.258]

Other DBs

RHEA:

14228

All links

Ontology (1)   
   KEGG BRITE (1)   
Pathway (6)   
   KEGG PATHWAY (6)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG RCLASS (2)   
   UMBBD-RN (1)   
Gene (13)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (12)   
All databases (29)   

Download RDF

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