KEGG   ORTHOLOGY: K19962
Entry
K19962                      KO                                     
Symbol
chnE
Name
6-oxohexanoate dehydrogenase [EC:1.2.1.63]
Pathway
map00930  Caprolactam degradation
map01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00930 Caprolactam degradation
    K19962  chnE; 6-oxohexanoate dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.1  With NAD+ or NADP+ as acceptor
    1.2.1.63  6-oxohexanoate dehydrogenase
     K19962  chnE; 6-oxohexanoate dehydrogenase
Other DBs
RN: R05099
COG: COG1012
GO: 0018483
Genes
PPJ: RK21_02870
AG: BAA86294(chnE)
Reference
  Authors
Iwaki H, Hasegawa Y, Teraoka M, Tokuyama T, Bergeron H, Lau PC
  Title
Identification of a transcriptional activator (ChnR) and a 6-oxohexanoate dehydrogenase (ChnE) in the cyclohexanol catabolic pathway in Acinetobacter sp. Strain NCIMB 9871 and localization of the genes that encode them.
  Journal
Appl Environ Microbiol 65:5158-62 (1999)
DOI:10.1128/AEM.65.11.5158-5162.1999
  Sequence

KEGG   ENZYME: 1.2.1.63
Entry
EC 1.2.1.63                 Enzyme                                 
Name
6-oxohexanoate dehydrogenase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
Sysname
6-oxohexanoate:NADP+ oxidoreductase
Reaction(IUBMB)
6-oxohexanoate + NADP+ + H2O = adipate + NADPH + 2 H+ [RN:R05099]
Reaction(KEGG)
R05099
Substrate
6-oxohexanoate [CPD:C06102];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Product
adipate [CPD:C06104];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Last step in the cyclohexanol degradation pathway in Acinetobacter sp.
History
EC 1.2.1.63 created 2000
Pathway
ec00930  Caprolactam degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K19962  6-oxohexanoate dehydrogenase
Genes
PPJRK21_02870
Reference
1  [PMID:856571]
  Authors
Davey JF, Trudgill PW.
  Title
The metabolism of trans-cyclohexan-1,2-diol by an Acinetobacter species.
  Journal
Eur J Biochem 74:115-27 (1977)
DOI:10.1111/j.1432-1033.1977.tb11373.x
Reference
2  [PMID:1261]
  Authors
Donoghue NA, Trudgill PW.
  Title
The metabolism of cyclohexanol by Acinetobacter NCIB 9871.
  Journal
Eur J Biochem 60:1-7 (1975)
DOI:10.1111/j.1432-1033.1975.tb20968.x
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.63
IUBMB Enzyme Nomenclature: 1.2.1.63
ExPASy - ENZYME nomenclature database: 1.2.1.63
UM-BBD (Biocatalysis/Biodegradation Database): 1.2.1.63
BRENDA, the Enzyme Database: 1.2.1.63
CAS: 62628-29-9

KEGG   REACTION: R05099
Entry
R05099                      Reaction                               
Name
6-oxohexanoate:NADP+ oxidoreductase
Definition
Adipate semialdehyde + NADP+ + H2O <=> Adipate + NADPH + H+
Equation
Reaction class
RC00001  C00005_C00006
RC00080  C06102_C06104
Enzyme
1.2.1.4         1.2.1.63
Pathway
rn00930  Caprolactam degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
Orthology
K14519  NADP-dependent aldehyde dehydrogenase [EC:1.2.1.4]
K19962  6-oxohexanoate dehydrogenase [EC:1.2.1.63]
Other DBs
RHEA: 13400

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