KEGG   ORTHOLOGY: K20576
Entry
K20576            Tight     KO                                     
Symbol
aprD3
Name
NADP-dependent dehydrogenase [EC:1.1.1.-]
Pathway
map00524  Neomycin, kanamycin and gentamicin biosynthesis
map01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00524 Neomycin, kanamycin and gentamicin biosynthesis
    K20576  aprD3; NADP-dependent dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.-
     K20576  aprD3; NADP-dependent dehydrogenase
Other DBs
RN: R11276 R11277
COG: COG1028
Genes
AG: CAF33052(aprD3)
Reference
  Authors
Lv M, Ji X, Zhao J, Li Y, Zhang C, Su L, Ding W, Deng Z, Yu Y, Zhang Q
  Title
Characterization of a C3 Deoxygenation Pathway Reveals a Key Branch Point in Aminoglycoside Biosynthesis.
  Journal
J Am Chem Soc 138:6427-35 (2016)
DOI:10.1021/jacs.6b02221
  Sequence
Reference
  Authors
Kim HJ, LeVieux J, Yeh YC, Liu HW
  Title
C3'-Deoxygenation of Paromamine Catalyzed by a Radical S-Adenosylmethionine Enzyme: Characterization of the Enzyme AprD4 and Its Reductase Partner AprD3.
  Journal
Angew Chem Int Ed Engl 55:3724-8 (2016)
DOI:10.1002/anie.201510635

KEGG   REACTION: R11276
Entry
R11276                      Reaction                               
Name
lividamine:NADP+ 4'-oxidoreductase
Definition
4'-Oxolividamine + NADPH + H+ <=> Lividamine + NADP+
Equation
Enzyme
1.1.1.-
Pathway
rn00524  Neomycin, kanamycin and gentamicin biosynthesis
rn01110  Biosynthesis of secondary metabolites
Orthology
K20576  NADP-dependent dehydrogenase [EC:1.1.1.-]

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