KEGG   ORTHOLOGY: K20932
Entry
K20932                      KO                                     

Symbol
K20932
Name
hydrazine synthase subunit [EC:1.7.2.7]
Pathway
map00910  Nitrogen metabolism
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00910 Nitrogen metabolism
    K20932  K20932; hydrazine synthase subunit
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.7  Acting on other nitrogenous compounds as donors
   1.7.2  With a cytochrome as acceptor
    1.7.2.7  hydrazine synthase
     K20932  K20932; hydrazine synthase subunit
Other DBs
RN: R09799
COG: COG3391
Genes
KST: KSMBR1_2703(hzsC_3)
BROC: IPI25_10120
BPIT: BPIT_07240 BPIT_26640
AG: CAJ73611
Reference
  Authors
Kartal B, Maalcke WJ, de Almeida NM, Cirpus I, Gloerich J, Geerts W, Op den Camp HJ, Harhangi HR, Janssen-Megens EM, Francoijs KJ, Stunnenberg HG, Keltjens JT, Jetten MS, Strous M
  Title
Molecular mechanism of anaerobic ammonium oxidation.
  Journal
Nature 479:127-30 (2011)
DOI:10.1038/nature10453
  Sequence

KEGG   ORTHOLOGY: K20933
Entry
K20933                      KO                                     

Symbol
K20933
Name
hydrazine synthase subunit [EC:1.7.2.7]
Pathway
map00910  Nitrogen metabolism
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00910 Nitrogen metabolism
    K20933  K20933; hydrazine synthase subunit
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.7  Acting on other nitrogenous compounds as donors
   1.7.2  With a cytochrome as acceptor
    1.7.2.7  hydrazine synthase
     K20933  K20933; hydrazine synthase subunit
Other DBs
RN: R09799
COG: COG1858
Genes
KST: KSMBR1_2704(hzsB_3)
BPIT: BPIT_07250 BPIT_07540 BPIT_26630
AG: CAJ73612
Reference
  Authors
Kartal B, Maalcke WJ, de Almeida NM, Cirpus I, Gloerich J, Geerts W, Op den Camp HJ, Harhangi HR, Janssen-Megens EM, Francoijs KJ, Stunnenberg HG, Keltjens JT, Jetten MS, Strous M
  Title
Molecular mechanism of anaerobic ammonium oxidation.
  Journal
Nature 479:127-30 (2011)
DOI:10.1038/nature10453
  Sequence

KEGG   ORTHOLOGY: K20934
Entry
K20934                      KO                                     

Symbol
K20934
Name
hydrazine synthase subunit [EC:1.7.2.7]
Pathway
map00910  Nitrogen metabolism
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00910 Nitrogen metabolism
    K20934  K20934; hydrazine synthase subunit
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.7  Acting on other nitrogenous compounds as donors
   1.7.2  With a cytochrome as acceptor
    1.7.2.7  hydrazine synthase
     K20934  K20934; hydrazine synthase subunit
Other DBs
RN: R09799
COG: COG0823
Genes
KST: KSMBR1_2713(hzsA_1)
BROC: IPI25_10105
BPIT: BPIT_07260 BPIT_26620
AG: CAJ73613
Reference
  Authors
Kartal B, Maalcke WJ, de Almeida NM, Cirpus I, Gloerich J, Geerts W, Op den Camp HJ, Harhangi HR, Janssen-Megens EM, Francoijs KJ, Stunnenberg HG, Keltjens JT, Jetten MS, Strous M
  Title
Molecular mechanism of anaerobic ammonium oxidation.
  Journal
Nature 479:127-30 (2011)
DOI:10.1038/nature10453
  Sequence

KEGG   ENZYME: 1.7.2.7
Entry
EC 1.7.2.7                  Enzyme                                 

Name
hydrazine synthase;
HZS
Class
Oxidoreductases;
Acting on other nitrogenous compounds as donors;
With a cytochrome as acceptor
Sysname
hydrazine:ferricytochrome-c oxidoreductase
Reaction(IUBMB)
hydrazine + H2O + 3 ferricytochrome c = nitric oxide + ammonium + 3 ferrocytochrome c [RN:R09799]
Reaction(KEGG)
R09799
Substrate
hydrazine [CPD:C05361];
H2O [CPD:C00001];
ferricytochrome c [CPD:C00125]
Product
nitric oxide [CPD:C00533];
ammonium;
ferrocytochrome c [CPD:C00126]
Comment
The enzyme, characterized from anaerobic ammonia oxidizers (anammox bacteria), is one of only a few enzymes that are known to form an N-N bond (other examples include EC 1.7.1.14, nitric oxide reductase [NAD(P)+, nitrous oxide-forming] and EC 4.8.1.1, L-piperazate synthase). The enzyme from the bacterium Candidatus Kuenenia stuttgartiensis is a dimer of heterotrimers and contains multiple c-type cytochromes.
History
EC 1.7.2.7 created 2016, modified 2021
Pathway
ec00910  Nitrogen metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K20932  hydrazine synthase subunit
K20933  hydrazine synthase subunit
K20934  hydrazine synthase subunit
Genes
KST: KSMBR1_2703(hzsC_3) KSMBR1_2704(hzsB_3) KSMBR1_2713(hzsA_1)
BROC: IPI25_10105 IPI25_10120
BPIT: BPIT_07240 BPIT_07250 BPIT_07260 BPIT_07540 BPIT_26620 BPIT_26630 BPIT_26640
Reference
1  [PMID:21964329]
  Authors
Kartal B, Maalcke WJ, de Almeida NM, Cirpus I, Gloerich J, Geerts W, Op den Camp HJ, Harhangi HR, Janssen-Megens EM, Francoijs KJ, Stunnenberg HG, Keltjens JT, Jetten MS, Strous M
  Title
Molecular mechanism of anaerobic ammonium oxidation.
  Journal
Nature 479:127-30 (2011)
DOI:10.1038/nature10453
  Sequence
Reference
2  [PMID:26479033]
  Authors
Dietl A, Ferousi C, Maalcke WJ, Menzel A, de Vries S, Keltjens JT, Jetten MS, Kartal B, Barends TR.
  Title
The inner workings of the hydrazine synthase multiprotein complex.
  Journal
Nature 527:394-7 (2015)
DOI:10.1038/nature15517
Other DBs
ExplorEnz - The Enzyme Database: 1.7.2.7
IUBMB Enzyme Nomenclature: 1.7.2.7
ExPASy - ENZYME nomenclature database: 1.7.2.7
BRENDA, the Enzyme Database: 1.7.2.7

KEGG   REACTION: R09799
Entry
R09799                      Reaction                               

Name
hydrazine:ferricytochrome-c oxidoreductase
Definition
Nitric oxide + Ammonia + 3 Ferrocytochrome c <=> Hydrazine + H2O + 3 Ferricytochrome c
Equation
Enzyme
Pathway
rn00910  Nitrogen metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
Orthology
K20932  hydrazine synthase subunit [EC:1.7.2.7]
K20933  hydrazine synthase subunit [EC:1.7.2.7]
K20934  hydrazine synthase subunit [EC:1.7.2.7]
Other DBs
RHEA: 49819

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