KEGG   ORTHOLOGY: K20979
Entry
K20979            Tight     KO                                     

Name
GES
Definition
geranyl diphosphate diphosphatase [EC:3.1.7.11]
Pathway
ko00902  Monoterpenoid biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00902 Monoterpenoid biosynthesis
    K20979  GES; geranyl diphosphate diphosphatase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.7  Diphosphoric-monoester hydrolases
    3.1.7.11  geranyl diphosphate diphosphatase
     K20979  GES; geranyl diphosphate diphosphatase
Other DBs
RN: R08396
Genes
AG: AAR11765(GES) CAD29734(GES)
Reference
  Authors
Iijima Y, Gang DR, Fridman E, Lewinsohn E, Pichersky E
  Title
Characterization of geraniol synthase from the peltate glands of sweet basil.
  Journal
Plant Physiol 134:370-9 (2004)
DOI:10.1104/pp.103.032946
  Sequence
Reference
  Authors
Yang T, Li J, Wang HX, Zeng Y
  Title
A geraniol-synthase gene from Cinnamomum tenuipilum.
  Journal
Phytochemistry 66:285-93 (2005)
DOI:10.1016/j.phytochem.2004.12.004
  Sequence

KEGG   ENZYME: 3.1.7.11
Entry
EC 3.1.7.11                 Enzyme                                 

Name
geranyl diphosphate diphosphatase;
geraniol synthase;
geranyl pyrophosphate pyrophosphatase;
GES;
CtGES
Class
Hydrolases;
Acting on ester bonds;
Diphosphoric-monoester hydrolases
Sysname
geranyl-diphosphate diphosphohydrolase
Reaction(IUBMB)
geranyl diphosphate + H2O = geraniol + diphosphate [RN:R08396]
Reaction(KEGG)
R08396
Substrate
geranyl diphosphate [CPD:C00341];
H2O [CPD:C00001]
Product
geraniol [CPD:C01500];
diphosphate [CPD:C00013]
Comment
Isolated from Ocimum basilicum (basil) and Cinnamomum tenuipile (camphor tree). Requires Mg2+ or Mn2+. Geraniol is labelled when formed in the presence of [18O]H2O. Thus mechanism involves a geranyl cation [1]. Neryl diphosphate is hydrolysed more slowly. May be the same as EC 3.1.7.3 monoterpenyl-diphosphatase.
History
EC 3.1.7.11 created 2012
Pathway
ec00902  Monoterpenoid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K20979  geranyl diphosphate diphosphatase
Reference
1  [PMID:14657409]
  Authors
Iijima Y, Gang DR, Fridman E, Lewinsohn E, Pichersky E
  Title
Characterization of geraniol synthase from the peltate glands of sweet basil.
  Journal
Plant Physiol 134:370-9 (2004)
DOI:10.1104/pp.103.032946
  Sequence
Reference
2  [PMID:15680985]
  Authors
Yang T, Li J, Wang HX, Zeng Y
  Title
A geraniol-synthase gene from Cinnamomum tenuipilum.
  Journal
Phytochemistry 66:285-93 (2005)
DOI:10.1016/j.phytochem.2004.12.004
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.1.7.11
IUBMB Enzyme Nomenclature: 3.1.7.11
ExPASy - ENZYME nomenclature database: 3.1.7.11
BRENDA, the Enzyme Database: 3.1.7.11

KEGG   REACTION: R08396
Entry
R08396                      Reaction                               

Name
geranyl-diphosphate diphosphohydrolase
Definition
Geranyl diphosphate + H2O <=> Geraniol + Diphosphate
Equation
Reaction class
RC00017  C00341_C01500
Enzyme
3.1.7.3         3.1.7.11
Pathway
rn00902  Monoterpenoid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K20979  geranyl diphosphate diphosphatase [EC:3.1.7.11]
Other DBs
RHEA: 32682

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