KEGG   ORTHOLOGY: K20983
Entry
K20983            Tight     KO                                     
Symbol
LOVD
Name
monacolin J acid methylbutanoate transferase [EC:2.3.1.238]
Pathway
map00997  Biosynthesis of various other secondary metabolites
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00893  Lovastatin biosynthesis, malonyl-CoA => lovastatin acid
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00997 Biosynthesis of various other secondary metabolites
    K20983  LOVD; monacolin J acid methylbutanoate transferase
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.238  monacolin J acid methylbutanoate transferase
     K20983  LOVD; monacolin J acid methylbutanoate transferase
Other DBs
RN: R11126
COG: COG1680
Genes
AG: AAD34555(LOVD)
Reference
  Authors
Xie X, Meehan MJ, Xu W, Dorrestein PC, Tang Y
  Title
Acyltransferase mediated polyketide release from a fungal megasynthase.
  Journal
J Am Chem Soc 131:8388-9 (2009)
DOI:10.1021/ja903203g
  Sequence

KEGG   ENZYME: 2.3.1.238
Entry
EC 2.3.1.238                Enzyme                                 
Name
monacolin J acid methylbutanoate transferase;
LovD
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
monacolin J acid:(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] (S)-2-methylbutanoate transferase
Reaction(IUBMB)
monacolin J acid + (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] = lovastatin acid + [2-methylbutanoate polyketide synthase]
Reaction(KEGG)
(other) R11126
Substrate
monacolin J acid [CPD:C20854];
(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase]
Product
lovastatin acid [CPD:C21130];
[2-methylbutanoate polyketide synthase]
Comment
The enzyme catalyses the ultimate reaction in the lovastatin biosynthesis pathway of the filamentous fungus Aspergillus terreus.
History
EC 2.3.1.238 created 2014
Pathway
ec00997  Biosynthesis of various other secondary metabolites
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K20983  monacolin J acid methylbutanoate transferase
Reference
1  [PMID:10334994]
  Authors
Kennedy J, Auclair K, Kendrew SG, Park C, Vederas JC, Hutchinson CR
  Title
Modulation of polyketide synthase activity by accessory proteins during lovastatin biosynthesis.
  Journal
Science 284:1368-72 (1999)
DOI:10.1126/science.284.5418.1368
  Sequence
Reference
2  [PMID:17113998]
  Authors
Xie X, Watanabe K, Wojcicki WA, Wang CC, Tang Y
  Title
Biosynthesis of lovastatin analogs with a broadly specific acyltransferase.
  Journal
Chem Biol 13:1161-9 (2006)
DOI:10.1016/j.chembiol.2006.09.008
  Sequence
Reference
3  [PMID:19530726]
  Authors
Xie X, Meehan MJ, Xu W, Dorrestein PC, Tang Y
  Title
Acyltransferase mediated polyketide release from a fungal megasynthase.
  Journal
J Am Chem Soc 131:8388-9 (2009)
DOI:10.1021/ja903203g
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.238
IUBMB Enzyme Nomenclature: 2.3.1.238
ExPASy - ENZYME nomenclature database: 2.3.1.238
BRENDA, the Enzyme Database: 2.3.1.238

KEGG   REACTION: R11126
Entry
R11126                      Reaction                               
Name
monacolin-J-acid:(S)-2-methylbutanoyl-[acp] (S)-2-methylbutanoyltransferase
Definition
Monacolin J acid + (S)-2-Methylbutanoyl-[acp] <=> Lovastatin acid + Acyl-carrier protein
Equation
Comment
Acy-carrier protein is acp domain of LOVF [KO:K20984].
Reaction class
RC00055  C20854_C21130
Enzyme
Pathway
rn00997  Biosynthesis of various other secondary metabolites
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00893  Lovastatin biosynthesis, malonyl-CoA => lovastatin acid
Orthology
K20983  monacolin J acid methylbutanoate transferase [EC:2.3.1.238]
Other DBs
RHEA: 43067

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