KEGG   ORTHOLOGY: K21105
Entry
K21105            Tight     KO                                     
Symbol
E3.1.1.102
Name
mono(ethylene terephthalate) hydrolase [EC:3.1.1.102]
Pathway
map00624  Polycyclic aromatic hydrocarbon degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00624 Polycyclic aromatic hydrocarbon degradation
    K21105  E3.1.1.102; mono(ethylene terephthalate) hydrolase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.1  Carboxylic-ester hydrolases
    3.1.1.102  mono(ethylene terephthalate) hydrolase
     K21105  E3.1.1.102; mono(ethylene terephthalate) hydrolase
Other DBs
RN: R11541
Genes
AG: GAP38911
Reference
  Authors
Yoshida S, Hiraga K, Takehana T, Taniguchi I, Yamaji H, Maeda Y, Toyohara K, Miyamoto K, Kimura Y, Oda K
  Title
A bacterium that degrades and assimilates poly(ethylene terephthalate).
  Journal
Science 351:1196-9 (2016)
DOI:10.1126/science.aad6359
  Sequence

KEGG   ENZYME: 3.1.1.102
Entry
EC 3.1.1.102                Enzyme                                 
Name
mono(ethylene terephthalate) hydrolase;
MHET hydrolase;
MHETase
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
Sysname
4-[(2-hydroxyethoxy)carbonyl]benzoate acylhydrolase
Reaction(IUBMB)
4-[(2-hydroxyethoxy)carbonyl]benzoate + H2O = terephthalate + ethylene glycol [RN:R11541]
Reaction(KEGG)
R11541
Substrate
4-[(2-hydroxyethoxy)carbonyl]benzoate [CPD:C21450];
H2O [CPD:C00001]
Product
terephthalate [CPD:C06337];
ethylene glycol [CPD:C01380]
Comment
The enzyme, isolated from the bacterium Ideonella sakaiensis, has no activity with poly(ethylene terephthalate) PET (cf. EC 3.1.1.101, poly(ethylene terephthalate) hydrolase).
History
EC 3.1.1.102 created 2016
Pathway
ec00624  Polycyclic aromatic hydrocarbon degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K21105  mono(ethylene terephthalate) hydrolase
Reference
1  [PMID:26965627]
  Authors
Yoshida S, Hiraga K, Takehana T, Taniguchi I, Yamaji H, Maeda Y, Toyohara K, Miyamoto K, Kimura Y, Oda K
  Title
A bacterium that degrades and assimilates poly(ethylene terephthalate).
  Journal
Science 351:1196-9 (2016)
DOI:10.1126/science.aad6359
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.102
IUBMB Enzyme Nomenclature: 3.1.1.102
ExPASy - ENZYME nomenclature database: 3.1.1.102
BRENDA, the Enzyme Database: 3.1.1.102

KEGG   REACTION: R11541
Entry
R11541                      Reaction                               
Name
4-[(2-hydroxyethoxy)carbonyl]benzoate acylhydrolase
Definition
4-(2-Hydroxyethoxycarbonyl)benzoate + H2O <=> Terephthalate + Ethylene glycol
Equation
Reaction class
RC00020  C06337_C21450
RC00041  C01380_C21450
Enzyme
Pathway
rn00624  Polycyclic aromatic hydrocarbon degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
Orthology
K21105  mono(ethylene terephthalate) hydrolase [EC:3.1.1.102]

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