KEGG   ORTHOLOGY: K21204
Entry
K21204            Tight     KO                                     
Symbol
OMT1
Name
5'-demethylyatein 5'-O-methyltransferase [EC:2.1.1.330]
Pathway
map00999  Biosynthesis of various plant secondary metabolites
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00902  Podophyllotoxin biosynthesis, coniferyl alcohol => podophyllotoxin
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00999 Biosynthesis of various plant secondary metabolites
    K21204  OMT1; 5'-demethylyatein 5'-O-methyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.330  5'-demethylyatein 5'-O-methyltransferase
     K21204  OMT1; 5'-demethylyatein 5'-O-methyltransferase
Other DBs
RN: R11545
Genes
AG: ALG05117(OMT1)
Reference
  Authors
Lau W, Sattely ES
  Title
Six enzymes from mayapple that complete the biosynthetic pathway to the etoposide aglycone.
  Journal
Science 349:1224-8 (2015)
DOI:10.1126/science.aac7202
  Sequence

KEGG   ENZYME: 2.1.1.330
Entry
EC 2.1.1.330                Enzyme                                 
Name
5'-demethylyatein 5'-O-methyltransferase;
OMT1 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:(-)-5'-demethylyatein 5'-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + (-)-5'-demethylyatein = S-adenosyl-L-homocysteine + (-)-yatein [RN:R11545]
Reaction(KEGG)
R11545
Substrate
S-adenosyl-L-methionine [CPD:C00019];
(-)-5'-demethylyatein [CPD:C21184]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
(-)-yatein [CPD:C10557]
Comment
The enzyme, characterized from the plant Sinopodophyllum hexandrum, is involved in the biosynthetic pathway of podophyllotoxin, a non-alkaloid toxin lignan whose derivatives are important anticancer drugs.
History
EC 2.1.1.330 created 2016
Pathway
ec00999  Biosynthesis of various plant secondary metabolites
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K21204  5'-demethylyatein 5'-O-methyltransferase
Reference
1  [PMID:26359402]
  Authors
Lau W, Sattely ES
  Title
Six enzymes from mayapple that complete the biosynthetic pathway to the etoposide aglycone.
  Journal
Science 349:1224-8 (2015)
DOI:10.1126/science.aac7202
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.330
IUBMB Enzyme Nomenclature: 2.1.1.330
ExPASy - ENZYME nomenclature database: 2.1.1.330
BRENDA, the Enzyme Database: 2.1.1.330

KEGG   REACTION: R11545
Entry
R11545                      Reaction                               
Name
S-adenosyl-L-methionine:(-)-5'-demethylyatein 5'-O-methyltransferase
Definition
S-Adenosyl-L-methionine + (-)-5'-Demethylyatein <=> S-Adenosyl-L-homocysteine + Dihydroanhydropodorhizol
Equation
Reaction class
RC00392  C10557_C21184
Enzyme
Pathway
rn00999  Biosynthesis of various plant secondary metabolites
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00902  Podophyllotoxin biosynthesis, coniferyl alcohol => podophyllotoxin
Orthology
K21204  5'-demethylyatein 5'-O-methyltransferase [EC:2.1.1.330]
Other DBs
RHEA: 49043

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