KEGG   ORTHOLOGY: K21301
Entry
K21301                      KO                                     

Symbol
oxyR, ctcR
Name
5a,11a-dehydrotetracycline reductase [EC:1.3.98.4]
Pathway
map00253  Tetracycline biosynthesis
map01057  Biosynthesis of type II polyketide products
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00780  Tetracycline/oxytetracycline biosynthesis, pretetramide => tetracycline/oxytetracycline
M00823  Chlortetracycline biosynthesis, pretetramide => chlortetracycline
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K21301  oxyR, ctcR; 5a,11a-dehydrotetracycline reductase
   00253 Tetracycline biosynthesis
    K21301  oxyR, ctcR; 5a,11a-dehydrotetracycline reductase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K21301  oxyR, ctcR; 5a,11a-dehydrotetracycline reductase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.98  With other, known, physiological acceptors
    1.3.98.4  5a,11a-dehydrotetracycline reductase
     K21301  oxyR, ctcR; 5a,11a-dehydrotetracycline reductase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Others
   K21301  oxyR, ctcR; 5a,11a-dehydrotetracycline reductase
Other DBs
RN: R05459 R09192
Genes
SPLA: CP981_34450
KAU: B6264_18540
AG: AAZ78341(oxyR) AEI98656(ctcM)
Reference
  Authors
Zhang W, Ames BD, Tsai SC, Tang Y
  Title
Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.
  Journal
Appl Environ Microbiol 72:2573-80 (2006)
DOI:10.1128/AEM.72.4.2573-2580.2006
  Sequence
Reference
  Authors
Wang P, Bashiri G, Gao X, Sawaya MR, Tang Y
  Title
Uncovering the enzymes that catalyze the final steps in oxytetracycline biosynthesis.
  Journal
J Am Chem Soc 135:7138-41 (2013)
DOI:10.1021/ja403516u

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