KEGG   ORTHOLOGY: K21373
Entry
K21373            Tight     KO                                     

Name
UGT8, UGT709C2
Definition
7-deoxyloganetic acid glucosyltransferase [EC:2.4.1.323]
Pathway
ko00902  Monoterpenoid biosynthesis
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00902 Monoterpenoid biosynthesis
    K21373  UGT8, UGT709C2; 7-deoxyloganetic acid glucosyltransferase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01003 Glycosyltransferases
    K21373  UGT8, UGT709C2; 7-deoxyloganetic acid glucosyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.323  7-deoxyloganetic acid glucosyltransferase
     K21373  UGT8, UGT709C2; 7-deoxyloganetic acid glucosyltransferase
Glycosyltransferases [BR:ko01003]
 Others
  Hydrophobic molecule
   K21373  UGT8, UGT709C2; 7-deoxyloganetic acid glucosyltransferase
Other DBs
RN: R10834
GO: 0102970
CAZy: GT1
Genes
AG: BAO01109(UGT709C2)
Reference
  Authors
Asada K, Salim V, Masada-Atsumi S, Edmunds E, Nagatoshi M, Terasaka K, Mizukami H, De Luca V
  Title
A 7-deoxyloganetic acid glucosyltransferase contributes a key step in secologanin biosynthesis in Madagascar periwinkle.
  Journal
Plant Cell 25:4123-34 (2013)
DOI:10.1105/tpc.113.115154
  Sequence

KEGG   ENZYME: 2.4.1.323
Entry
EC 2.4.1.323                Enzyme                                 

Name
7-deoxyloganetic acid glucosyltransferase;
UGT8
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-alpha-D-glucose:7-deoxyloganetate O-D-glucosyltransferase
Reaction(IUBMB)
UDP-alpha-D-glucose + 7-deoxyloganetate = UDP + 7-deoxyloganate [RN:R10834]
Reaction(KEGG)
R10834
Substrate
UDP-alpha-D-glucose [CPD:C00029];
7-deoxyloganetate [CPD:C20789]
Product
UDP [CPD:C00015];
7-deoxyloganate [CPD:C11636]
Comment
Isolated from the plant Catharanthus roseus (Madagascar periwinkle). Involved in loganin and secologanin biosynthesis. Does not react with 7-deoxyloganetin. cf. EC 2.4.1.324 7-deoxyloganetin glucosyltransferase.
History
EC 2.4.1.323 created 2014
Pathway
ec00902  Monoterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K21373  7-deoxyloganetic acid glucosyltransferase
Reference
1  [PMID:24104568]
  Authors
Asada K, Salim V, Masada-Atsumi S, Edmunds E, Nagatoshi M, Terasaka K, Mizukami H, De Luca V
  Title
A 7-deoxyloganetic acid glucosyltransferase contributes a key step in secologanin biosynthesis in Madagascar periwinkle.
  Journal
Plant Cell 25:4123-34 (2013)
DOI:10.1105/tpc.113.115154
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.323
IUBMB Enzyme Nomenclature: 2.4.1.323
ExPASy - ENZYME nomenclature database: 2.4.1.323
BRENDA, the Enzyme Database: 2.4.1.323

KEGG   REACTION: R10834
Entry
R10834                      Reaction                               

Name
UDP-alpha-D-glucose:7-deoxyloganetate O-D-glucosyltransferase
Definition
UDP-glucose + 7-Deoxyloganetate <=> UDP + 7-Deoxyloganate
Equation
Reaction class
RC00005  C00015_C00029
RC00049  C11636_C20789
Enzyme
Pathway
rn00902  Monoterpenoid biosynthesis
rn01110  Biosynthesis of secondary metabolites
Orthology
K21373  7-deoxyloganetic acid glucosyltransferase [EC:2.4.1.323]
Other DBs
RHEA: 39898

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