KEGG   ORTHOLOGY: K22089
Entry
K22089                      KO                                     

Name
STOX, DBOX
Definition
tetrahydroprotoberberine oxidase [EC:1.3.3.8]
Pathway
ko00950  Isoquinoline alkaloid biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00945  Sanguinarine biosynthesis, (S)-reticuline => sanguinarine
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00950 Isoquinoline alkaloid biosynthesis
    K22089  STOX, DBOX; tetrahydroprotoberberine oxidase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.3  With oxygen as acceptor
    1.3.3.8  tetrahydroberberine oxidase
     K22089  STOX, DBOX; tetrahydroprotoberberine oxidase
Other DBs
RN: R02880 R03722 R04703 R08795 R11748
GO: 0050328
Genes
PSOM: 113274966 113303200
AG: ADY15026(STOX) AGL44334(DBOX)
Reference
  Authors
Hagel JM, Beaudoin GA, Fossati E, Ekins A, Martin VJ, Facchini PJ
  Title
Characterization of a flavoprotein oxidase from opium poppy catalyzing the final steps in sanguinarine and papaverine biosynthesis.
  Journal
J Biol Chem 287:42972-83 (2012)
DOI:10.1074/jbc.M112.420414
  Sequence
Reference
  Authors
Gesell A, Chavez ML, Kramell R, Piotrowski M, Macheroux P, Kutchan TM
  Title
Heterologous expression of two FAD-dependent oxidases with (S)-tetrahydroprotoberberine oxidase activity from Arge mone mexicana and Berberis wilsoniae in insect cells.
  Journal
Planta 233:1185-97 (2011)
DOI:10.1007/s00425-011-1357-4
  Sequence

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