KEGG   ORTHOLOGY: K22094
Entry
K22094            Tight     KO                                     

Name
CYP82X2
Definition
(S)-1-hydroxy-N-methylcanadine 13-hydroxylase [EC:1.14.14.163]
Pathway
map00950  Isoquinoline alkaloid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00946  Noscapine biosynthesis, (S)-reticuline => noscapine
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00950 Isoquinoline alkaloid biosynthesis
    K22094  CYP82X2; (S)-1-hydroxy-N-methylcanadine 13-hydroxylase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K22094  CYP82X2; (S)-1-hydroxy-N-methylcanadine 13-hydroxylase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.163  (S)-1-hydroxy-N-methylcanadine 13-hydroxylase
     K22094  CYP82X2; (S)-1-hydroxy-N-methylcanadine 13-hydroxylase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, plant type
  CYP82 family
   K22094  CYP82X2; (S)-1-hydroxy-N-methylcanadine 13-hydroxylase
Other DBs
RN: R11688
Genes
PSOM: 113322152
AG: AFB74616(CYP82X2)
Reference
  Authors
Winzer T, Gazda V, He Z, Kaminski F, Kern M, Larson TR, Li Y, Meade F, Teodor R, Vaistij FE, Walker C, Bowser TA, Graham IA
  Title
A Papaver somniferum 10-gene cluster for synthesis of the anticancer alkaloid noscapine.
  Journal
Science 336:1704-8 (2012)
DOI:10.1126/science.1220757
  Sequence
Reference
  Authors
Dang TT, Chen X, Facchini PJ
  Title
Acetylation serves as a protective group in noscapine biosynthesis in opium poppy.
  Journal
Nat Chem Biol 11:104-6 (2015)
DOI:10.1038/nchembio.1717

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