KEGG   ORTHOLOGY: K22252
Entry
K22252                      KO                                     
Symbol
tld
Name
GDP-6-deoxy-D-talose 4-dehydrogenase [EC:1.1.1.135]
Pathway
map00051  Fructose and mannose metabolism
map00520  Amino sugar and nucleotide sugar metabolism
map00541  O-Antigen nucleotide sugar biosynthesis
map01100  Metabolic pathways
map01250  Biosynthesis of nucleotide sugars
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00051 Fructose and mannose metabolism
    K22252  tld; GDP-6-deoxy-D-talose 4-dehydrogenase
   00520 Amino sugar and nucleotide sugar metabolism
    K22252  tld; GDP-6-deoxy-D-talose 4-dehydrogenase
  09107 Glycan biosynthesis and metabolism
   00541 O-Antigen nucleotide sugar biosynthesis
    K22252  tld; GDP-6-deoxy-D-talose 4-dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.135  GDP-6-deoxy-D-talose 4-dehydrogenase
     K22252  tld; GDP-6-deoxy-D-talose 4-dehydrogenase
Other DBs
RN: R03396 R03398
COG: COG0451
GO: 0047916
Genes
CIF: AL515_09815
AHN: NCTC12129_03345(gmd_1)
ASUB: NLZ15_07795
YEL: LC20_01981
YAL: AT01_3984
YIN: CH53_3320
YRO: CH64_55
YAK: ACZ76_01900
YMA: DA391_07895
YHI: D5F51_11755
SMAR: SM39_1026
SPLY: Q5A_007985(tld)
PAM: PANA_2484(gmd)
AAN: D7S_01295
XFA: XF_0610
XFT: PD_1544(rmd)
XCC: XCC0608(rmd)
XCB: XC_3626
XCA: xcc-b100_3743(rmd)
XCP: XCR_0760
XCV: XCV3717(rmd)
XAX: XACM_3491
XPH: XppCFBP6546_16350(XppCFBP6546P_16350)
PPU: PP_1800(rmd)
PPT: PPS_1442
PPI: YSA_02163
PPX: T1E_3059
PPUT: L483_06555
PPUD: DW66_1721
PMON: X969_05140
PMOT: X970_05115
PSB: Psyr_0915
PFL: PFL_5490
PKC: PKB_5494
PSTT: CH92_12755
PSEO: OM33_05165
TCX: Tcr_1679
MEJ: Q7A_1107
MEC: Q7C_2301
TSE: THMIRHAS_04630(rmd)
RPI: Rpic_1157
REH: H16_A2899(h16_A2899)
BMA: BMAA1710
BMAL: DM55_3289
BMAE: DM78_4219
BMAQ: DM76_3987
BMAI: DM57_07430
BMAF: DM51_3407
BMAZ: BM44_3225
BMAB: BM45_4064
BPS: BPSS1689
BPM: BURPS1710b_A0759(rmd)
BPSE: BDL_5043
BPSM: BBQ_4452
BPSU: BBN_5143
BPSD: BBX_4209
BPK: BBK_4407
BPSH: DR55_3579
BPSA: BBU_4338
BPSO: X996_5857
BUT: X994_5418
BTHA: DR62_5644
BVE: AK36_4366
BCJ: BCAM1003
BCEO: I35_4922
BMU: Bmul_4613
BMUL: NP80_3955
BCED: DM42_4085
BTEI: WS51_03265
BPSL: WS57_08770
BSTG: WT74_24280
BGU: KS03_1585
BXE: Bxe_A3804
BXB: DR64_1481
BPH: Bphy_2320
BFN: OI25_839
HYF: DTO96_100937(tld)
CABA: SBC2_28360(tld)
PUT: PT7_3166
AMIM: MIM_c06860
POL: Bpro_4013
HPSE: HPF_17885(tld)
BBAG: E1O_12910
MFA: Mfla_1272
ABRE: pbN1_26690
CSHO: CSHOW_1843
SUN: SUN_0343
NIS: NIS_1385
JAN: Jann_4281
RSU: NHU_00139
SPHR: BSY17_2983
ATX: GCD22_00851(tld) GCD22_02377(tld)
FPS: FP1641(rmd)
 » show all
Reference
  Authors
Suzuki N, Nakano Y, Yoshida Y, Nezu T, Terada Y, Yamashita Y, Koga T
  Title
Guanosine diphosphate-4-keto-6-deoxy-d-mannose reductase in the pathway for the synthesis of GDP-6-deoxy-d-talose in Actinobacillus actinomycetemcomitans.
  Journal
Eur J Biochem 269:5963-71 (2002)
DOI:10.1046/j.1432-1033.2002.03331.x
  Sequence
[aan:D7S_01295]
Reference
  Authors
Suzuki N, Nakano Y, Yoshida Y, Nakao H, Yamashita Y, Koga T
  Title
Genetic analysis of the gene cluster for the synthesis of serotype a-specific polysaccharide antigen in Aactinobacillus actinomycetemcomitans.
  Journal
Biochim Biophys Acta 1517:135-8 (2000)
DOI:10.1016/S0167-4781(00)00229-3

KEGG   ENZYME: 1.1.1.135
Entry
EC 1.1.1.135                Enzyme                                 
Name
GDP-6-deoxy-D-talose 4-dehydrogenase;
guanosine diphospho-6-deoxy-D-talose dehydrogenase;
GDP-6-deoxy-D-talose:NAD(P)+ 4-oxidoreductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
GDP-6-deoxy-alpha-D-talose:NAD(P)+ 4-oxidoreductase
Reaction(IUBMB)
GDP-6-deoxy-alpha-D-talose + NAD(P)+ = GDP-4-dehydro-alpha-D-rhamnose + NAD(P)H + H+ [RN:R03396 R03398]
Reaction(KEGG)
R03396 R03398
Substrate
GDP-6-deoxy-alpha-D-talose [CPD:C02977];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
GDP-4-dehydro-alpha-D-rhamnose [CPD:C01222];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
History
EC 1.1.1.135 created 1972, modified 1976
Pathway
ec00051  Fructose and mannose metabolism
ec00520  Amino sugar and nucleotide sugar metabolism
ec00541  O-Antigen nucleotide sugar biosynthesis
ec01100  Metabolic pathways
Orthology
K22252  GDP-6-deoxy-D-talose 4-dehydrogenase
Genes
CIFAL515_09815
AHNNCTC12129_03345(gmd_1)
ASUBNLZ15_07795
YELLC20_01981
YALAT01_3984
YINCH53_3320
YROCH64_55
YAKACZ76_01900
YMADA391_07895
YHID5F51_11755
YCAF0T03_14235
SMARSM39_1026
SPLYQ5A_007985(tld)
SLQM495_07475 M495_07570
SERASer39006_021535
SERQCWC46_21545
RAQRahaq2_0608
ROXBV494_19820
DDADd703_3276
LBQCKQ53_08325
LPOPI6N93_13505
EGEEM595_2372
PAMPANA_2484(gmd)
PAGGAL522_16715
AAND7S_01295
AACTACT75_06325
XFAXF_0610
XFTPD_1544(rmd)
XFMXfasm12_1700
XFNXfasM23_1629
XFFXFLM_01935
XFLP303_07475
XFSD934_11835
XFHXFHB_02480
XTWAB672_08855
XCCXCC0608(rmd)
XCBXC_3626
XCAxcc-b100_3743(rmd)
XCPXCR_0760
XCVXCV3717(rmd)
XAXXACM_3491
XFUXFF4834R_chr34890(rmd)
XSASB85_09725
XFRBER92_15650
XVEBJD12_08865
XHRXJ27_12055
XGABI317_04110
XPHXppCFBP6546_16350(XppCFBP6546P_16350)
XHYFZ025_05570
XCZEBN15_02415
PJPLAG73_14170
LABLA76x_1077
LAQGLA29479_2075
LAREHIV01_010355
RGLCS053_03535
DTXATSB10_36230
DYEEO087_14115
DCSISN74_16800
LRZBJI69_11350
LPYFIV34_04010
LANHKR767_02895
VCXVAA049_3439
PPUPP_1800(rmd)
PPWPputW619_1409
PPTPPS_1442
PPIYSA_02163
PPXT1E_3059
PPUTL483_06555
PPUDDW66_1721
PMONX969_05140
PMOTX970_05115
PSBPsyr_0915
PSPPSPPH_0952
PAMGBKM19_007295
PAVLBKM03_06230
PVDCFBP1590__4578
PSYIMME58_04490
PFLPFL_5490
PKCPKB_5494
PCPJM49_09370
PRHLT40_09355
PFKPFAS1_20070
PUMHGP31_09110
PMOEHV782_020695
PPRGHU725_006420
PGFJ0G10_21695
PJUL1P09_06295
PSTTCH92_12755
PBMCL52_10710
MBAHHYN46_03275
PSEOOM33_05165
OSGBST96_12985
FRXF7310_02840
AIIE4K63_06530
TCXTcr_1679
THIOAYJ59_05010
MEJQ7A_1107
MECQ7C_2301
TSETHMIRHAS_04630(rmd)
THISHZT40_02280
TUNJ9260_12900
TWNL2Y54_20855
TTITHITH_09895
HNAHneap_0493
HAZA9404_03650
HSXHNO51_11450
HSVHNO53_09355
MGEOCFI10_17110
VCWGJQ55_04055
GSNYC6258_05311
CHIZHQ393_16180
RSLRPSI07_2511
RPIRpic_1157
RINACS15_2522
REHH16_A2899(h16_A2899)
COXE0W60_23615
BMABMAA1710
BMVBMASAVP1_1659
BMALDM55_3289
BMAEDM78_4219
BMAQDM76_3987
BMAIDM57_07430
BMAFDM51_3407
BMAZBM44_3225
BMABBM45_4064
BPSBPSS1689
BPMBURPS1710b_A0759(rmd)
BPLBURPS1106A_A2297
BPDBURPS668_A2436
BPSEBDL_5043
BPSMBBQ_4452
BPSUBBN_5143
BPSDBBX_4209
BPZBP1026B_II1807
BPQBPC006_II2270
BPKBBK_4407
BPSHDR55_3579
BPSABBU_4338
BPSOX996_5857
BUTX994_5418
BTEBTH_I1332 BTH_II0689
BTQBTQ_2602 BTQ_3980
BTJBTJ_3093 BTJ_5012
BTZBTL_1023 BTL_3480
BTDBTI_4202 BTI_803
BTVBTHA_1116 BTHA_4405
BTHEBTN_364 BTN_5467
BTHMBTRA_1231 BTRA_3476
BTHADR62_5644
BTHLBG87_1220 BG87_3435
BOKDM82_2469 DM82_5939
BOCBG90_2265 BG90_2396 BG90_4699
BUUWS70_25600
BSAVWS86_04210 WS86_27345
BHGI6G56_16665 I6G56_32045
BVIBcep1808_4471
BVEAK36_4366
BURBcep18194_B2116
BCMBcenmc03_3560
BCHBcen2424_0881 Bcen2424_3969
BCJBCAM1003
BCENDM39_3953 DM39_691
BCEWDM40_1542 DM40_3969
BCEOI35_4922
BAMBamb_0760 Bamb_3357
BACBamMC406_0771 BamMC406_3862
BMJBMULJ_03898
BMUBmul_4613
BMKDM80_3816 DM80_797
BMULNP80_3955
BCTGEM_2644 GEM_4794
BCEDDM42_4085
BCEPAPZ15_19420
BDLAK34_2293 AK34_4461
BPYRABD05_09450 ABD05_16790
BCONNL30_07355 NL30_11345
BUBBW23_4729 BW23_852
BDFWI26_03895 WI26_18605
BLATWK25_04125 WK25_22415
BTEIWS51_03265
BSEMWJ12_04025 WJ12_25275
BPSLWS57_08770
BMECWJ16_04060 WJ16_23945
BSTGWT74_24280
BSTLBBJ41_18295
BANNJFN94_04200 JFN94_22580
BGLbglu_1g06560
BGUKS03_1585
BUGBC1001_0652
BGFBC1003_0746
BGDbgla_1g06990 bgla_2g18040
BGOBM43_2088 BM43_5522
BUKMYA_0777 MYA_4688
BULBW21_3742 BW21_899
BUQAC233_03225
BGPBGL_1c06400(rmd) BGL_2c17930
BPLAbpln_1g06320 bpln_2g18700
BUDAQ610_03890 AQ610_22195
BUMAXG89_02015
BUIAX768_11740
BURKDM992_17205 DM992_30720
BXEBxe_A3804
BXBDR64_1481
BPHBphy_2320
BGEBC1002_0607
BPXBUPH_04545
BPYBphyt_0877
BUZAYM40_03080
BFNOI25_839
BCAIK788_0007820
PSPWBJG93_09825
PARABTO02_07040
PARBCJU94_01855
PHSC2L64_14005
PTERC2L65_12150
PGPCUJ91_03365
PCJCUJ87_03240
PTSCUJ90_03215
PCAFDSC91_006041
PMEGFNZ07_18110
PTROG5S35_14810
PGISI6I06_08465 I6I06_08530
PACPFAZ97_03340 FAZ97_20760
PACSFAZ98_16985
PDIOPDMSB3_0752
HYFDTO96_100937(tld)
CABASBC2_28360(tld)
BUOBRPE64_DCDS10750
PUTPT7_3166
AMIMMIM_c06860
PACRFXN63_22995
POLBpro_4013
ACKC380_03140
ACIDCBP33_02615
AANTHUK68_19130
VAPVapar_0756
VPDVAPA_1c08230
CSERCCO03_02130
CAQTKAQ61_06435
HPSEHPF_17885(tld)
DIHG7047_18270
DAERH9K75_08275
DRGH9K76_03700
DIADtpsy_0560
RBNRBXJA2T_06510
CPRACPter91_0941
MNRACZ75_22250
MASWAM586_25155
MASSCR152_11340
MTIMDIR46_16365
MASYDPH57_17270
MANCIV454_04085
MFYHH212_10910
MASZC9I28_04680
MALIEYF70_01225
MUMFCL38_17350
MFLAGO485_12700
MPLIE1742_13165
DUGHH213_07575
UPVEJN92_06825
UPIEJG51_010235
GLCJQN73_10335
BBAGE1O_12910
MFAMfla_1272
SULFCAP31_11785
ABREpbN1_26690
FLEKI610_09410
AZIAzCIB_3826
AZDCDA09_18395
AZRCJ010_21715
TAKTharo_0938
TDNSuden_1703
SKUSulku_2119
CRXCRECT_0860
CSHOCSHOW_1843
SULSSdiek1_2358
SULTFA592_04065
SUNSUN_0343
NISNIS_1385
DPRDespr_0531
JANJann_4281
RSUNHU_00139
RHMB5V46_02115
DONBSK21_15500
NPPPP1Y_Lpl613
SSEDH9L14_04875
SSING7078_00740
SJPSJA_C1-30290
SYBTZ53_02305
SPHRBSY17_2983
SBARH5V43_11355
POQKZX46_08455
ATXGCD22_00851(tld) GCD22_02377(tld)
PARHI5S86_07855
SSYIEKG83_10515
LEOAMK43_11170
FPSFP1641(rmd)
FPCFPSM_01168
FPYFPG101_05725
FPOFPG3_09840
FPQIB65_08150
FPVIA03_07930
FPWIA04_07865
FPKIA06_07870
MUTGVT53_17520
AQBD1818_14315
AQAD1815_16960
DINSelin_0211
DAPDacet_2693
 » show all
Reference
1  [PMID:14209931]
  Authors
MARKOVITZ A.
  Title
BIOSYNTHESIS OF GUANOSINE DIPHOSPHATE D-RHAMNOSE AND GUANOSINE DIPHOSPHATE D-TALOMETHYLOSE FROM GUANOSINE DIPHOSPHATE ALPHA-D-MANNOSE.
  Journal
J Biol Chem 239:2091-8 (1964)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.135
IUBMB Enzyme Nomenclature: 1.1.1.135
ExPASy - ENZYME nomenclature database: 1.1.1.135
BRENDA, the Enzyme Database: 1.1.1.135
CAS: 37250-66-1

KEGG   REACTION: R03396
Entry
R03396                      Reaction                               
Name
GDP-6-deoxy-D-talose:NAD+ 4-oxidoreductase
Definition
GDP-6-deoxy-D-talose + NAD+ <=> GDP-4-dehydro-6-deoxy-D-mannose + NADH + H+
Equation
Comment
NADP+ (see R03398)
Reaction class
RC00001  C00003_C00004
RC00182  C01222_C02977
Enzyme
1.1.1.135       1.1.1.187
Pathway
rn00051  Fructose and mannose metabolism
rn00520  Amino sugar and nucleotide sugar metabolism
rn00541  O-Antigen nucleotide sugar biosynthesis
rn01100  Metabolic pathways
rn01250  Biosynthesis of nucleotide sugars
Orthology
K22252  GDP-6-deoxy-D-talose 4-dehydrogenase [EC:1.1.1.135]
Other DBs
RHEA: 10731

KEGG   REACTION: R03398
Entry
R03398                      Reaction                               
Name
GDP-6-deoxy-D-talose:NADP+ 4-oxidoreductase
Definition
GDP-6-deoxy-D-talose + NADP+ <=> GDP-4-dehydro-6-deoxy-D-mannose + NADPH + H+
Equation
Comment
NAD+ (see R03396)
Reaction class
RC00001  C00005_C00006
RC00182  C01222_C02977
Enzyme
1.1.1.135       1.1.1.187
Pathway
rn00051  Fructose and mannose metabolism
rn00520  Amino sugar and nucleotide sugar metabolism
rn00541  O-Antigen nucleotide sugar biosynthesis
rn01100  Metabolic pathways
rn01250  Biosynthesis of nucleotide sugars
Orthology
K22252  GDP-6-deoxy-D-talose 4-dehydrogenase [EC:1.1.1.135]
Other DBs
RHEA: 10727

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