KEGG   ORTHOLOGY: K22275
Entry
K22275            Tight     KO                                     
Symbol
NS5A
Name
HCV non-structural protein 5A
Pathway
map03230  Viral genome structure
map03240  Viral replication
map05160  Hepatitis C
map05203  Viral carcinogenesis
Network
nt06110  MAPK signaling (viruses and bacteria)
nt06114  PI3K signaling (viruses)
nt06123  TNF signaling (viruses and bacteria)
nt06130  Cell cycle (viruses)
nt06131  Apoptosis (viruses and bacteria)
nt06137  OAS/RNase L pathway (viruses)
nt06163  Hepatitis C virus (HCV)
nt06210  ERK signaling
nt06214  PI3K signaling
nt06263  Hepatocellular carcinoma
  Element
N00272  HCV NS5A to PI3K signaling pathway
N00273  HCV NS5A to oligoadenylate synthetase (OAS)/RNase L pathway
N00274  HCV NS5A to RAS-ERK signaling pathway
N00520  HCV NS5A to p21-cell cycle G1/S
N00524  HCV NS5A to extrinsic apoptotic pathway
N00525  HCV NS5A to TNF-NFKB signaling pathway
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03230 Viral genome structure
    K22275  NS5A; HCV non-structural protein 5A
   03240 Viral replication
    K22275  NS5A; HCV non-structural protein 5A
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    K22275  NS5A; HCV non-structural protein 5A
  09172 Infectious disease: viral
   05160 Hepatitis C
    K22275  NS5A; HCV non-structural protein 5A
 09180 Brite Hierarchies
  09185 Viral protein families
   03200 Viral proteins
    K22275  NS5A; HCV non-structural protein 5A
Viral proteins [BR:ko03200]
 +ssRNA viruses
  Hepatitis C virus
   K22275  NS5A; HCV non-structural protein 5A
Genes
VP: 951475-9(NS5A)
Reference
  Authors
Badillo A, Receveur-Brechot V, Sarrazin S, Cantrelle FX, Delolme F, Fogeron ML, Molle J, Montserret R, Bockmann A, Bartenschlager R, Lohmann V, Lippens G, Ricard-Blum S, Hanoulle X, Penin F
  Title
Overall Structural Model of NS5A Protein from Hepatitis C Virus and Modulation by Mutations Confering Resistance of Virus Replication to Cyclosporin A.
  Journal
Biochemistry 56:3029-3048 (2017)
DOI:10.1021/acs.biochem.7b00212
  Sequence
Reference
  Authors
Scheel TK, Rice CM
  Title
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies.
  Journal
Nat Med 19:837-49 (2013)
DOI:10.1038/nm.3248

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