KEGG   ORTHOLOGY: K22435
Entry
K22435            Tight     KO                                     
Symbol
PSIK
Name
4-hydroxytryptamine kinase [EC:2.7.1.222]
Pathway
map00901  Indole alkaloid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00962  Psilocybin biosynthesis, tryptophan => psilocybin
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00901 Indole alkaloid biosynthesis
    K22435  PSIK; 4-hydroxytryptamine kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.222  4-hydroxytryptamine kinase
     K22435  PSIK; 4-hydroxytryptamine kinase
Other DBs
RN: R08480 R11933
COG: COG4857
Genes
PCUB: JR316_0010785
AG: ASU62237(psiK)
Reference
  Authors
Fricke J, Blei F, Hoffmeister D
  Title
Enzymatic Synthesis of Psilocybin.
  Journal
Angew Chem Int Ed Engl 56:12352-12355 (2017)
DOI:10.1002/anie.201705489
  Sequence

KEGG   ENZYME: 2.7.1.222
Entry
EC 2.7.1.222                Enzyme                                 
Name
4-hydroxytryptamine kinase;
PsiK
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
ATP:4-hydroxytryptamine 4-phosphotransferase
Reaction(IUBMB)
ATP + 4-hydroxytryptamine = ADP + 4-hydroxytryptamine 4-phosphate [RN:R11933]
Reaction(KEGG)
R11933;
(other) R08480
Substrate
ATP [CPD:C00002];
4-hydroxytryptamine [CPD:C21762]
Product
ADP [CPD:C00008];
4-hydroxytryptamine 4-phosphate [CPD:C21778]
Comment
Also acts on 4-hydroxy-L-tryptophan in vitro. Isolated from the fungus Psilocybe cubensis. Involved in the biosynthesis of the psychoactive compound psilocybin.
History
EC 2.7.1.222 created 2017
Pathway
ec00901  Indole alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K22435  4-hydroxytryptamine kinase
Genes
PCUBJR316_0010785
Reference
1  [PMID:28763571]
  Authors
Fricke J, Blei F, Hoffmeister D
  Title
Enzymatic Synthesis of Psilocybin.
  Journal
Angew Chem Int Ed Engl 56:12352-12355 (2017)
DOI:10.1002/anie.201705489
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.222
IUBMB Enzyme Nomenclature: 2.7.1.222
ExPASy - ENZYME nomenclature database: 2.7.1.222
BRENDA, the Enzyme Database: 2.7.1.222

KEGG   REACTION: R11933
Entry
R11933                      Reaction                               
Name
ATP:4-hydroxytryptamine 4-phosphotransferase
Definition
ATP + 4-Hydroxytryptamine <=> ADP + Norbaeocystin
Equation
Reaction class
RC00002  C00002_C00008
RC00151  C21762_C21778
Enzyme
Pathway
rn00901  Indole alkaloid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00962  Psilocybin biosynthesis, tryptophan => psilocybin
Orthology
K22435  4-hydroxytryptamine kinase [EC:2.7.1.222]
Other DBs
RHEA: 55567

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