Transferring one-carbon groups;
S-adenosyl-L-methionine + 3-O-acetyl-4'-O-demethylpapaveroxine = S-adenosyl-L-homocysteine + 3-O-acetylpapaveroxine [RN:
This activity is part of the noscapine biosynthesis pathway, as characterized in the plant Papaver somniferum (opium poppy). It is catalysed by heterodimeric complexes of the OMT2 gene product and the product of either OMT3 or 6OMT. OMT2 is the catalytic subunit in both complexes.
EC 188.8.131.522 created 2018
ec00950 Isoquinoline alkaloid biosynthesis
ec01110 Biosynthesis of secondary metabolites
K23157 3-O-acetyl-4'-O-demethylpapaveroxine 4'-O-methyltransferase subunit OMT2
Li Y, Smolke CD
Engineering biosynthesis of the anticancer alkaloid noscapine in yeast.
Park MR, Chen X, Lang DE, Ng KKS, Facchini PJ
Heterodimeric O-methyltransferases involved in the biosynthesis of noscapine in opium poppy.
ExPASy - ENZYME nomenclature database: 184.108.40.2062