KEGG   ORTHOLOGY: K23276
Entry
K23276            Tight     KO                                     

Name
CYP72A224
Definition
7-deoxyloganate 7-hydroxylase [EC:1.14.14.85]
Pathway
ko00902  Monoterpenoid biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00902 Monoterpenoid biosynthesis
    K23276  CYP72A224; 7-deoxyloganate 7-hydroxylase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K23276  CYP72A224; 7-deoxyloganate 7-hydroxylase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.85  7-deoxyloganate 7-hydroxylase
     K23276  CYP72A224; 7-deoxyloganate 7-hydroxylase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, plant type
  CYP72 family
   K23276  CYP72A224; 7-deoxyloganate 7-hydroxylase
Other DBs
RN: R03556 R05832
GO: 0050595
Genes
AG: AHK60834(CYP72A224)
Reference
  Authors
Miettinen K, Dong L, Navrot N, Schneider T, Burlat V, Pollier J, Woittiez L, van der Krol S, Lugan R, Ilc T, Verpoorte R, Oksman-Caldentey KM, Martinoia E, Bouwmeester H, Goossens A, Memelink J, Werck-Reichhart D
  Title
The seco-iridoid pathway from Catharanthus roseus.
  Journal
Nat Commun 5:3606 (2014)
DOI:10.1038/ncomms4606
  Sequence

KEGG   ENZYME: 1.14.14.85
Entry
EC 1.14.14.85               Enzyme                                 

Name
7-deoxyloganate 7-hydroxylase;
CYP72A224 (gene name);
7-deoxyloganin 7-hydroxylase (incorrect);
7-deoxyloganin,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (7alpha-hydroxylating) (incorrect)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
7-deoxyloganate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (7alpha-hydroxylating)
Reaction(IUBMB)
7-deoxyloganate + [reduced NADPH---hemoprotein reductase] + O2 = loganate + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R05832]
Reaction(KEGG)
R05832;
(other) R03556
Substrate
7-deoxyloganate [CPD:C11636];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
loganate [CPD:C01512];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
The enzyme, characterized from the plant Catharanthus roseus, is a cytochrome P-450 (heme-thiolate) enzyme. It catalyses a reaction in the pathway leading to biosynthesis of monoterpenoid indole alkaloids.
History
EC 1.14.14.85 created 2002 as EC 1.14.13.74, transferred 2018 to EC 1.14.14.85, modified 2018
Pathway
ec00902  Monoterpenoid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K23276  7-deoxyloganate 7-hydroxylase
Reference
1  [PMID:11524113]
  Authors
Katano N, Yamamoto H, Iio R, Inoue K.
  Title
7-Deoxyloganin 7-hydroxylase in Lonicera japonica cell cultures.
  Journal
Phytochemistry 58:53-8 (2001)
DOI:10.1016/S0031-9422(01)00181-9
Reference
2  [PMID:24710322]
  Authors
Miettinen K, Dong L, Navrot N, Schneider T, Burlat V, Pollier J, Woittiez L, van der Krol S, Lugan R, Ilc T, Verpoorte R, Oksman-Caldentey KM, Martinoia E, Bouwmeester H, Goossens A, Memelink J, Werck-Reichhart D
  Title
The seco-iridoid pathway from Catharanthus roseus.
  Journal
Nat Commun 5:3606 (2014)
DOI:10.1038/ncomms4606
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.85
IUBMB Enzyme Nomenclature: 1.14.14.85
ExPASy - ENZYME nomenclature database: 1.14.14.85
BRENDA, the Enzyme Database: 1.14.14.85
CAS: 335305-40-3

KEGG   REACTION: R03556
Entry
R03556                      Reaction                               

Name
7-deoxyloganin,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (7alpha-hydroxylating)
Definition
Deoxyloganin + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> Loganin + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
Reaction class
RC00661  C01433_C06071
Enzyme
Pathway
rn00902  Monoterpenoid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K23276  7-deoxyloganate 7-hydroxylase [EC:1.14.14.85]
Other DBs
RHEA: 11455

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