KEGG   ORTHOLOGY: K23494
Entry
K23494            Tight     KO                                     

Symbol
CYP71AY1
Name
alstonine synthase [EC:1.14.14.-]
Pathway
map00901  Indole alkaloid biosynthesis
map01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00901 Indole alkaloid biosynthesis
    K23494  CYP71AY1; alstonine synthase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K23494  CYP71AY1; alstonine synthase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.-  
     K23494  CYP71AY1; alstonine synthase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, plant type
  CYP71 family
   K23494  CYP71AY1; alstonine synthase
Other DBs
RN: R05849 R12282
Genes
AG: AHK60849(CYP71AY1)
Reference
  Authors
Miettinen K, Dong L, Navrot N, Schneider T, Burlat V, Pollier J, Woittiez L, van der Krol S, Lugan R, Ilc T, Verpoorte R, Oksman-Caldentey KM, Martinoia E, Bouwmeester H, Goossens A, Memelink J, Werck-Reichhart D
  Title
The seco-iridoid pathway from Catharanthus roseus.
  Journal
Nat Commun 5:3606 (2014)
DOI:10.1038/ncomms4606
  Sequence
Reference
  Authors
Dang TT, Franke J, Carqueijeiro IST, Langley C, Courdavault V, O'Connor SE
  Title
Sarpagan bridge enzyme has substrate-controlled cyclization and aromatization modes.
  Journal
Nat Chem Biol 14:760-763 (2018)
DOI:10.1038/s41589-018-0078-4

KEGG   REACTION: R12282
Entry
R12282                      Reaction                               

Definition
Tetrahydroalstonine + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> Alstonine + [Oxidized NADPH---hemoprotein reductase] + 2 H2O + 2 H+
Equation
Comment
alstonine synthase
Reaction class
RC01641  C09028_C11682
Enzyme
1.14.14.-
Pathway
rn00901  Indole alkaloid biosynthesis
rn01110  Biosynthesis of secondary metabolites
Orthology
K23494  alstonine synthase [EC:1.14.14.-]

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