KEGG   ORTHOLOGY: K23756
Entry
K23756                      KO                                     
Symbol
ACSM1, LAE
Name
medium-chain acyl-CoA ligase / lipoate-activating enzyme [EC:6.2.1.2]
Pathway
map00650  Butanoate metabolism
map00785  Lipoic acid metabolism
map01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00650 Butanoate metabolism
    K23756  ACSM1, LAE; medium-chain acyl-CoA ligase / lipoate-activating enzyme
  09108 Metabolism of cofactors and vitamins
   00785 Lipoic acid metabolism
    K23756  ACSM1, LAE; medium-chain acyl-CoA ligase / lipoate-activating enzyme
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01004 Lipid biosynthesis proteins
    K23756  ACSM1, LAE; medium-chain acyl-CoA ligase / lipoate-activating enzyme
Enzymes [BR:ko01000]
 6. Ligases
  6.2  Forming carbon-sulfur bonds
   6.2.1  Acid-thiol ligases
    6.2.1.2  medium-chain acyl-CoA ligase
     K23756  ACSM1, LAE; medium-chain acyl-CoA ligase / lipoate-activating enzyme
Lipid biosynthesis proteins [BR:ko01004]
 Acyl-CoA synthetase
  Short/medium chain acyl-CoA synthetase
   K23756  ACSM1, LAE; medium-chain acyl-CoA ligase / lipoate-activating enzyme
Other DBs
RN: R01176 R07770
GO: 0047760
Genes
HSA: 116285(ACSM1)
PTR: 101058263(ACSM1)
PPS: 100972336
GGO: 101153106(ACSM1)
PON: 100444065 100444423
MCC: 696498(ACSM1)
MCF: 102123380(ACSM1)
MTHB: 126944947
CSAB: 103229298(ACSM1)
CATY: 105586560(ACSM1)
PANU: 101018326(ACSM1)
TGE: 112614782(ACSM1)
RRO: 104682075(ACSM1)
RBB: 108513946(ACSM1)
TFN: 117087530(ACSM1)
PTEH: 111551197(ACSM1)
CSYR: 103272478
MMUR: 105855230(ACSM1)
OGA: 100961636
MMU: 117147(Acsm1)
MCAL: 110297667(Acsm1)
MPAH: 110326344(Acsm1)
RNO: 361638(Acsm1)
MCOC: 116102869(Acsm1)
MUN: 110547837(Acsm1)
CGE: 100767739
MAUA: 101829208(Acsm1)
PLEU: 114692159(Acsm1)
MORG: 121457640(Acsm1)
MFOT: 126502317
AAMP: 119825600
NGI: 103742763(Acsm1)
HGL: 101712893(Acsm1)
CPOC: 100729957
CCAN: 109696824(Acsm1)
DORD: 105982171
DSP: 122096209
NCAR: 124970589
OCU: 100352247(ACSM1)
OPI: 101533894
TUP: 102480423(ACSM1)
AML: 100474845(ACSM1)
UMR: 103668661(ACSM1)
UAH: 113270722
UAR: 123775568(ACSM1)
ELK: 111156117
LLV: 125090827
MPUF: 101688355(ACSM1)
ORO: 101367835(ACSM1)
EJU: 114199691(ACSM1)
ZCA: 113933034(ACSM1)
MLX: 118024125
FCA: 101083474
PYU: 121024605
PBG: 122471595
LRUF: 124517964
PTG: 102954003
PPAD: 109278419
AJU: 106970530
BTA: 282576(ACSM1)
BOM: 102271152(ACSM1)
BIU: 109578603(ACSM1)
BBUB: 102400565(ACSM1)
CHX: 102182274(ACSM1)
OAS: 101120375(ACSM1)
ODA: 120875532(ACSM1)
CCAD: 122433375(ACSM1)
CFR: 102504896(ACSM1)
CBAI: 105073707(ACSM1)
CDK: 105091129(ACSM1)
VPC: 102535111(ACSM1)
LVE: 103089263
OOR: 101287714
DLE: 111171037
PCAD: 112064828
MYB: 102260013
MYD: 102762433
MNA: 107544731
HAI: 109386530(ACSM1)
AJM: 119040944
MMF: 118642295
RFQ: 117019409(ACSM1)
RAY: 107516833
MJV: 108400240(ACSM1)
SARA: 101543727(ACSM1)
LAV: 100668576(ACSM1)
TMU: 101348158
MDO: 100619197
GAS: 123234404
SHR: 100932766
PCW: 110193490
 » show all
Reference
  Authors
Fujiwara K, Takeuchi S, Okamura-Ikeda K, Motokawa Y.
  Title
Purification, characterization, and cDNA cloning of lipoate-activating enzyme from bovine liver.
  Journal
J Biol Chem 276:28819-23 (2001)
DOI:10.1074/jbc.M101748200
  Sequence
[bta:282576]
Reference
  Authors
Kasuya F, Tatsuki T, Ohta M, Kawai Y, Igarashi K
  Title
Purification, characterization, and mass spectrometric sequencing of a medium chain acyl-CoA synthetase from mouse liver mitochondria and comparisons with the homologues of rat and bovine.
  Journal
Protein Expr Purif 47:405-14 (2006)
DOI:10.1016/j.pep.2005.11.006

KEGG   REACTION: R07770
Entry
R07770                      Reaction                               
Definition
ATP + (R)-Lipoate <=> Diphosphate + Lipoyl-AMP
Equation
Reaction class
RC00043  C16238_C16241
Enzyme
Pathway
rn00785  Lipoic acid metabolism
rn01100  Metabolic pathways
Orthology
K03800  lipoate---protein ligase [EC:6.3.1.20]
K23756  medium-chain acyl-CoA ligase / lipoate-activating enzyme [EC:6.2.1.2]
Other DBs
RHEA: 12916

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