KEGG   ORTHOLOGY: K24442
Entry
K24442                      KO                                     
Symbol
xacA
Name
D-xylose 1-dehydrogenase (NADP+, D-xylono-1,4-lactone-forming) [EC:1.1.1.424]
Pathway
map00040  Pentose and glucuronate interconversions
map01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00040 Pentose and glucuronate interconversions
    K24442  xacA; D-xylose 1-dehydrogenase (NADP+, D-xylono-1,4-lactone-forming)
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.424  D-xylose 1-dehydrogenase (NADP+, D-xylono-1,4-lactone-forming)
     K24442  xacA; D-xylose 1-dehydrogenase (NADP+, D-xylono-1,4-lactone-forming)
Other DBs
RN: R12643
COG: COG0673
Genes
SSPB: CP982_35245
NANO: G5V58_11635
HHB: Hhub_4012 Hhub_4091
HNO: LT974_07990
HJE: HacjB3_02295 HacjB3_03200 HacjB3_05780
HALR: EFA46_009975 EFA46_010985 EFA46_011180
HAAD: MW046_12180 MW046_12920 MW046_14155 MW046_14340
HALX: M0R89_09680 M0R89_16690
HAXZ: M0R88_09955 M0R88_16895
SALI: L593_08020
HMA: pNG7191(gfo2) rrnAC3034(gfo6)
HHI: HAH_0291 HAH_5355(gfo4)
HUT: Huta_2274
HTI: HTIA_1971
HMU: Hmuk_2533
HALL: LC1Hm_1813(xdh)
HDS: HSR122_1642(mviM3)
HWA: HQ_3202A
HWC: Hqrw_3764
HVO: HVO_A0330 HVO_B0028(xacA)
NAT: NJ7G_0683
 » show all
Reference
  Authors
Johnsen U, Schonheit P
  Title
Novel xylose dehydrogenase in the halophilic archaeon Haloarcula marismortui.
  Journal
J Bacteriol 186:6198-207 (2004)
DOI:10.1128/JB.186.18.6198-6207.2004
  Sequence
[hma:rrnAC3034]
Reference
  Authors
Sutter JM, Johnsen U, Schonheit P
  Title
Characterization of a pentonolactonase involved in D-xylose and L-arabinose catabolism in the haloarchaeon Haloferax volcanii.
  Journal
FEMS Microbiol Lett 364:3898818 (2017)
DOI:10.1093/femsle/fnx140
  Sequence
[hvo:HVO_B0028]

KEGG   ENZYME: 1.1.1.424
Entry
EC 1.1.1.424                Enzyme                                 
Name
D-xylose 1-dehydrogenase (NADP+, D-xylono-1,4-lactone-forming);
xacA (gene name);
xdh (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
D-xylose:NADP+ 1-oxidoreductase (D-xylono-1,4-lactone-forming)
Reaction(IUBMB)
D-xylose + NADP+ = D-xylono-1,4-lactone + NADPH + H+ [RN:R12643]
Reaction(KEGG)
R12643
Substrate
D-xylose [CPD:C00181];
NADP+ [CPD:C00006]
Product
D-xylono-1,4-lactone [CPD:C02753];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme, which participates in the degradation of D-xylose, has been characterized from several halophilic archaeal species. cf. EC 1.1.1.179, D-xylose 1-dehydrogenase (NADP+, D-xylono-1,5-lactone-forming).
History
EC 1.1.1.424 created 2020
Pathway
ec00040  Pentose and glucuronate interconversions
ec01100  Metabolic pathways
Orthology
K24442  D-xylose 1-dehydrogenase (NADP+, D-xylono-1,4-lactone-forming)
Genes
SSPBCP982_35245
NANOG5V58_11635
HHBHhub_4012 Hhub_4091
HNOLT974_07990
HJEHacjB3_02295 HacjB3_03200 HacjB3_05780
HALREFA46_009975 EFA46_010985 EFA46_011180
HAADMW046_12180 MW046_12920 MW046_14155 MW046_14340
HALXM0R89_09680 M0R89_16690
HAXZM0R88_09955 M0R88_16895
SALIL593_08020
HMApNG7191(gfo2) rrnAC3034(gfo6)
HHIHAH_0291 HAH_5355(gfo4)
HHNHISP_01540 HISP_19955
HABSG26_09370 SG26_18100
HTABVU17_01425 BVU17_16040
HALJG9465_01150 G9465_11050
HSINKDQ40_12210 KDQ40_20300
HUTHuta_2274
HTIHTIA_1971
HALAHrd1104_00795
HMUHmuk_2533
HALZE5139_15810
HALLLC1Hm_1813(xdh)
HAZPGBQ70_15830
HALIBV210_12335
HDSHSR122_1642(mviM3)
HRRHZS55_09950 HZS55_16380 HZS55_21940
HPELHZS54_15205 HZS54_19155 HZS54_25430
HLTI7X12_14445 I7X12_19035 I7X12_19515
HDOMUK72_10720
HWAHQ_3202A
HWCHqrw_3764
HVOHVO_A0330 HVO_B0028(xacA)
HGIABY42_15585
HALEG3A49_05315 G3A49_07045
HALMFCF25_13805
HLAHlac_1560 Hlac_2241
HALPDOS48_12410
HALBEKH57_12905
HEZZEO776_13375
HALQHrr1229_008625
HSSJ7656_02875
HSAIHPS36_08250
HAZZKI388_12275
SRUBC2R22_01265 C2R22_14900
HALNB4589_002340 B4589_002525
HALGHUG10_06145 HUG10_08065 HUG10_16045
HALUHUG12_08080
HMPK6T50_05830 K6T50_17825
HREK6T36_05565 K6T36_16885
HRMK6T25_10215 K6T25_13160
HACBHbl1158_12160 Hbl1158_15055
HDFAArcSl_0519
HAHHalar_3506
HTUHtur_0531 Htur_4116 Htur_4497
HDABB347_11275
HSALJMJ58_06465 JMJ58_22330 JMJ58_23275
HLOJ0X27_10455
HAKZJ0X25_10045
HXAHalxa_0582 Halxa_1863 Halxa_3767 Halxa_3993
NATNJ7G_0683
NPENatpe_3458
NVRFEJ81_08200 FEJ81_16840
NPLFGF80_15705
NAYHYG81_01595 HYG81_01625
HALYHYG82_17880
HJTDVR14_07440
NOUNatoc_1104 Natoc_3157
HLRHALLA_04515 HALLA_06500
NASGCU68_19960
SAWLNGM29_12785
 » show all
Reference
1  [PMID:15342590]
  Authors
Johnsen U, Schonheit P
  Title
Novel xylose dehydrogenase in the halophilic archaeon Haloarcula marismortui.
  Journal
J Bacteriol 186:6198-207 (2004)
DOI:10.1128/JB.186.18.6198-6207.2004
  Sequence
[hma:rrnAC3034]
Reference
2  [PMID:19584053]
  Authors
Johnsen U, Dambeck M, Zaiss H, Fuhrer T, Soppa J, Sauer U, Schonheit P
  Title
D-xylose degradation pathway in the halophilic archaeon Haloferax volcanii.
  Journal
J Biol Chem 284:27290-303 (2009)
DOI:10.1074/jbc.M109.003814
  Sequence
[hvo:HVO_B0028]
Reference
3  [PMID:28854683]
  Authors
Sutter JM, Johnsen U, Schonheit P
  Title
Characterization of a pentonolactonase involved in D-xylose and L-arabinose catabolism in the haloarchaeon Haloferax volcanii.
  Journal
FEMS Microbiol Lett 364:3898818 (2017)
DOI:10.1093/femsle/fnx140
  Sequence
[hvo:HVO_B0028]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.424
IUBMB Enzyme Nomenclature: 1.1.1.424
ExPASy - ENZYME nomenclature database: 1.1.1.424
BRENDA, the Enzyme Database: 1.1.1.424

KEGG   REACTION: R12643
Entry
R12643                      Reaction                               
Name
D-xylose:NADP+ 1-oxidoreductase (D-xylono-1,4-lactone-forming)
Definition
D-Xylose + NADP+ <=> D-Xylono-1,4-lactone + NADPH + H+
Equation
Enzyme
Pathway
rn00040  Pentose and glucuronate interconversions
rn01100  Metabolic pathways
Orthology
K24442  D-xylose 1-dehydrogenase (NADP+, D-xylono-1,4-lactone-forming) [EC:1.1.1.424]

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