KEGG   ORTHOLOGY: K24556
Entry
K24556                      KO                                     

Symbol
tylG3
Name
tylactone synthase 3
Pathway
map00522  Biosynthesis of 12-, 14- and 16-membered macrolides
map01052  Type I polyketide structures
map01100  Metabolic pathways
Module
M00773  Tylosin biosynthesis, methylmalonyl-CoA + malonyl-CoA => tylactone => tylosin
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K24556  tylG3; tylactone synthase 3
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K24556  tylG3; tylactone synthase 3
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K24556  tylG3; tylactone synthase 3
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide synthase (PKS)
  Modular type I PKS
   cis-AT PKS
    Tylactone synthase
     K24556  tylG3; tylactone synthase 3
Other DBs
RN: R06448
Genes
SCYG: S1361_05090(eryA2)
AG: AAB66506(tylG3)
Reference
  Authors
Rawlings BJ.
  Title
Type I polyketide biosynthesis in bacteria (part B).
  Journal
Nat Prod Rep 18:231-81 (2001)
DOI:10.1039/B100191O
Reference
  Authors
Butler AR, Bate N, Cundliffe E
  Title
Impact of thioesterase activity on tylosin biosynthesis in Streptomyces fradiae.
  Journal
Chem Biol 6:287-92 (1999)
DOI:10.1016/S1074-5521(99)80074-X
  Sequence

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