KEGG   ORTHOLOGY: K24566
Entry
K24566                      KO                                     

Symbol
oleAIII
Name
8,8a-deoxyoleandolide synthase 3
Pathway
map00522  Biosynthesis of 12-, 14- and 16-membered macrolides
map01052  Type I polyketide structures
map01100  Metabolic pathways
Module
M00775  Oleandomycin biosynthesis, malonyl-CoA + methylmalonyl-CoA => 8,8a-deoxyoleandolide => oleandomycin
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K24566  oleAIII; 8,8a-deoxyoleandolide synthase 3
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K24566  oleAIII; 8,8a-deoxyoleandolide synthase 3
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K24566  oleAIII; 8,8a-deoxyoleandolide synthase 3
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide synthase (PKS)
  Modular type I PKS
   cis-AT PKS
    Oleandomycin synthase
     K24566  oleAIII; 8,8a-deoxyoleandolide synthase 3
Other DBs
RN: R06453
Genes
AG: AAA19695(oleAIII)
Reference
  Authors
Shah S, Xue Q, Tang L, Carney JR, Betlach M, McDaniel R
  Title
Cloning, characterization and heterologous expression of a polyketide synthase and P-450 oxidase involved in the biosynthesis of the antibiotic oleandomycin.
  Journal
J Antibiot (Tokyo) 53:502-8 (2000)
DOI:10.7164/antibiotics.53.502
Reference
PMID:8107683
  Authors
Swan DG, Rodriguez AM, Vilches C, Mendez C, Salas JA
  Title
Characterisation of a Streptomyces antibioticus gene encoding a type I polyketide synthase which has an unusual coding sequence.
  Journal
Mol Gen Genet 242:358-62 (1994)
DOI:10.1007/BF00280426
  Sequence

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