KEGG   ORTHOLOGY: K24856
Entry
K24856                      KO                                     
Symbol
AFLM
Name
NADPH-dependent reductase
Pathway
map00254  Aflatoxin biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00937  Aflatoxin biosynthesis, malonyl-CoA => aflatoxin B1
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00254 Aflatoxin biosynthesis
    K24856  AFLM; NADPH-dependent reductase
Other DBs
RN: R10480 R10481
COG: COG1028
Genes
PAN: PODANSg8553
ANI: AN7806.2
AOR: AO090026000019
AFV: AFLA_006300
APUU: APUU_20033S
FFU: CLAFUR5_14375
Reference
PMID:1339261
  Authors
Skory CD, Chang PK, Cary J, Linz JE
  Title
Isolation and characterization of a gene from Aspergillus parasiticus associated with the conversion of versicolorin A to sterigmatocystin in aflatoxin biosynthesis.
  Journal
Appl Environ Microbiol 58:3527-37 (1992)
DOI:10.1128/AEM.58.11.3527-3537.1992
  Sequence

KEGG   ORTHOLOGY: K24438
Entry
K24438                      KO                                     
Symbol
AFLN, STCS, CYP59A1
Name
sterigmatocystin biosynthesis cytochrome P450 monooxygenase
Pathway
map00254  Aflatoxin biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00937  Aflatoxin biosynthesis, malonyl-CoA => aflatoxin B1
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00254 Aflatoxin biosynthesis
    K24438  AFLN, STCS, CYP59A1; sterigmatocystin biosynthesis cytochrome P450 monooxygenase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K24438  AFLN, STCS, CYP59A1; sterigmatocystin biosynthesis cytochrome P450 monooxygenase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, fungi type
  CYP59 family
   K24438  AFLN, STCS, CYP59A1; sterigmatocystin biosynthesis cytochrome P450 monooxygenase
Other DBs
RN: R10480 R10481
COG: COG2124
Genes
PAN: PODANSg8555
CHIG: CH63R_07337
ANI: AN7808.2
AOR: AO090026000020
AFV: AFLA_006298
APUU: APUU_20036S
Reference
PMID:7486998
  Authors
Keller NP, Segner S, Bhatnagar D, Adams TH
  Title
stcS, a putative P-450 monooxygenase, is required for the conversion of versicolorin A to sterigmatocystin in Aspergillus nidulans.
  Journal
Appl Environ Microbiol 61:3628-32 (1995)
DOI:10.1128/AEM.61.10.3628-3632.1995
  Sequence
[ani:AN7808.2]
Reference
  Authors
Kelly DE, Krasevec N, Mullins J, Nelson DR
  Title
The CYPome (Cytochrome P450 complement) of Aspergillus nidulans.
  Journal
Fungal Genet Biol 46 Suppl 1:S53-61 (2009)
DOI:10.1016/j.fgb.2008.08.010

KEGG   ORTHOLOGY: K24857
Entry
K24857                      KO                                     
Symbol
AFLX
Name
oxidoreductase AflX
Pathway
map00254  Aflatoxin biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00937  Aflatoxin biosynthesis, malonyl-CoA => aflatoxin B1
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00254 Aflatoxin biosynthesis
    K24857  AFLX; oxidoreductase AflX
Other DBs
RN: R10480 R10481
Genes
PAN: PODANSg8573
ANI: AN7810.2
AFV: AFLA_006286
APUU: APUU_20055A
FFU: CLAFUR5_10127 CLAFUR5_14279
Reference
  Authors
Cary JW, Ehrlich KC, Bland JM, Montalbano BG.
  Title
The aflatoxin biosynthesis cluster gene, aflX, encodes an oxidoreductase involved in conversion of versicolorin A to demethylsterigmatocystin.
  Journal
Appl Environ Microbiol 72:1096-101 (2006)
DOI:10.1128/AEM.72.2.1096-1101.2006
  Sequence

KEGG   ORTHOLOGY: K24858
Entry
K24858                      KO                                     
Symbol
AFLY
Name
oxidoreductase AflY
Pathway
map00254  Aflatoxin biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00937  Aflatoxin biosynthesis, malonyl-CoA => aflatoxin B1
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00254 Aflatoxin biosynthesis
    K24858  AFLY; oxidoreductase AflY
Other DBs
RN: R10480 R10481
Genes
PAN: PODANSg8574
ANI: AN7809.2
AOR: AO090026000031
AFV: AFLA_006286
APUU: APUU_20056S
TRG: TRUGW13939_07449
Reference
  Authors
Ehrlich KC, Montalbano B, Boue SM, Bhatnagar D
  Title
An aflatoxin biosynthesis cluster gene encodes a novel oxidase required for conversion of versicolorin a to sterigmatocystin.
  Journal
Appl Environ Microbiol 71:8963-5 (2005)
DOI:10.1128/AEM.71.12.8963-8965.2005
  Sequence

KEGG   REACTION: R10480
Entry
R10480                      Reaction                               
Definition
Versicolorin B <=> Dihydrodemethylsterigmatocystin
Equation
Comment
multi-step reaction
Reaction class
RC03160  C20444_C20575
Pathway
rn00254  Aflatoxin biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K24438  sterigmatocystin biosynthesis cytochrome P450 monooxygenase
K24856  NADPH-dependent reductase
K24857  oxidoreductase AflX
K24858  oxidoreductase AflY

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