KEGG   MODULE: M00697
Entry
M00697            Signature Module                                 

Name
Multidrug resistance, efflux pump MdtEF-TolC
Definition
K07690 K18898+K18899+K12340
Diagram
M00697

Orthology
K07690  
evgA, bvgA; two-component system, NarL family, response regulator EvgA [COG:COG2197] [GO:0000156]
K18898  
mdtE; membrane fusion protein [COG:COG0845] [TC:8.A.1.6.3 2.A.6.2]
K18899  
mdtF; multidrug efflux pump [COG:COG0841] [TC:2.A.6.2.13]
K12340  
tolC; outer membrane channel protein [COG:COG1538] [TC:1.B.17 2.A.6.2]
Class
Signature modules; Gene set; Drug resistance
Comment
Resistance mechanism: limitation of drug accumulation as a result of active drug efflux
Reference
  Authors
Nishino K, Yamaguchi A
  Title
EvgA of the two-component signal transduction system modulates production of the yhiUV multidrug transporter in Escherichia coli.
  Journal
J Bacteriol 184:2319-23 (2002)
DOI:10.1128/JB.184.8.2319-2323.2002
Reference
  Authors
Fernandez L, Hancock RE
  Title
Adaptive and mutational resistance: role of porins and efflux pumps in drug resistance.
  Journal
Clin Microbiol Rev 25:661-81 (2012)
DOI:10.1128/CMR.00043-12
Reference
  Authors
Poole K
  Title
Efflux-mediated multiresistance in Gram-negative bacteria.
  Journal
Clin Microbiol Infect 10:12-26 (2004)
DOI:10.1111/j.1469-0691.2004.00763.x

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