KEGG   MODULE: M00700
Entry
M00700            Signature Module                                 

Name
Multidrug resistance, efflux pump AbcA
Definition
(K18906,K18907) K18104
Diagram
M00700

Orthology
K18906  
mgrA; MarR family transcriptional regulator, multiple gene regulator MgrA [COG:COG1846]
K18907  
norG; GntR family transcriptional regulator, regulator for abcA and norABC [COG:COG1167]
K18104  
abcA, bmrA; ATP-binding cassette, subfamily B, bacterial AbcA/BmrA [EC:3.6.3.44] [COG:COG1132] [GO:0008559] [TC:3.A.1.117 3.A.1.123]
Class
Signature modules; Gene set; Drug resistance
Comment
Resistance mechanism: limitation of drug accumulation as a result of active drug efflux
Reference
  Authors
Truong-Bolduc QC, Hooper DC
  Title
The transcriptional regulators NorG and MgrA modulate resistance to both quinolones and beta-lactams in Staphylococcus aureus.
  Journal
J Bacteriol 189:2996-3005 (2007)
DOI:10.1128/JB.01819-06
Reference
  Authors
Villet RA, Truong-Bolduc QC, Wang Y, Estabrooks Z, Medeiros H, Hooper DC
  Title
Regulation of expression of abcA and its response to environmental conditions.
  Journal
J Bacteriol 196:1532-9 (2014)
DOI:10.1128/JB.01406-13
Reference
  Authors
Fernandez L, Hancock RE
  Title
Adaptive and mutational resistance: role of porins and efflux pumps in drug resistance.
  Journal
Clin Microbiol Rev 25:661-81 (2012)
DOI:10.1128/CMR.00043-12

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