KEGG   MODULE: M00702
Entry
M00702            Signature Module                                 

Name
Multidrug resistance, efflux pump NorB
Definition
(K18906,K18907) K08170
Diagram
M00702

Orthology
K18906  
mgrA; MarR family transcriptional regulator, multiple gene regulator MgrA [COG:COG1846]
K18907  
norG; GntR family transcriptional regulator, regulator for abcA and norABC [COG:COG1167]
K08170  
BLTL; MFS transporter, DHA2 family, multidrug resistance protein [COG:COG0477] [TC:2.A.1.3]
Class
Signature modules; Gene set; Drug resistance
Comment
Resistance mechanism: limitation of drug accumulation as a result of active drug efflux
Reference
  Authors
Truong-Bolduc QC, Dunman PM, Strahilevitz J, Projan SJ, Hooper DC
  Title
MgrA is a multiple regulator of two new efflux pumps in Staphylococcus aureus.
  Journal
J Bacteriol 187:2395-405 (2005)
DOI:10.1128/JB.187.7.2395-2405.2005
Reference
  Authors
Truong-Bolduc QC, Hooper DC
  Title
The transcriptional regulators NorG and MgrA modulate resistance to both quinolones and beta-lactams in Staphylococcus aureus.
  Journal
J Bacteriol 189:2996-3005 (2007)
DOI:10.1128/JB.01819-06
Reference
  Authors
Truong-Bolduc QC, Dunman PM, Eidem T, Hooper DC
  Title
Transcriptional profiling analysis of the global regulator NorG, a GntR-like protein of Staphylococcus aureus.
  Journal
J Bacteriol 193:6207-14 (2011)
DOI:10.1128/JB.05847-11
Reference
  Authors
Fernandez L, Hancock RE
  Title
Adaptive and mutational resistance: role of porins and efflux pumps in drug resistance.
  Journal
Clin Microbiol Rev 25:661-81 (2012)
DOI:10.1128/CMR.00043-12

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