KEGG   MODULE: M00837
Entry
M00837            Pathway   Module                                 
Name
Prodigiosin biosynthesis, L-proline => prodigiosin
Definition
K21780+K21781 K21782 K21783 K21784 K21785 K21786
K21428 K21778 K21779
K21787
Diagram
M00837

Orthology
K21780  
pigI; L-proline---[L-prolyl-carrier protein] ligase [EC:6.2.1.53] [RN:R06746]
K21781  
pigG; peptidyl carrier protein [RN:R06746]
K21782  
pigA; L-prolyl-PCP dehydrogenase [EC:1.3.8.14] [RN:R06747]
K21783  
pigJ; beta-ketoacyl ACP synthase [EC:2.3.1.-] [RN:R11665]
K21784  
pigH; 4-hydroxy-2,2'-bipyrrole-5-methanol synthase [RN:R11667]
K21785  
pigM; 4-hydroxy-2,2'-bipyrrole-5-methanol dehydrogenase [RN:R11668 R11669]
K21786  
pigF; 4-hydroxy-2,2'-bipyrrole-5-carbaldehyde O-methyltransferase [EC:2.1.1.-] [RN:R11670]
K21428  
pigD; 3-acetyloctanal synthase [EC:2.2.1.12] [RN:R11141]
K21778  
pigE; 3-acetyloctanal aminotransferase [EC:2.6.1.-] [RN:R11672]
K21779  
pigB; 2-methyl-3-n-amyl-dihydropyrrolel dehydrogenase [RN:R11661]
K21787  
pigC; prodigiosin/undecylprodigiosin synthetase [RN:R11662]
Class
Pathway modules; Biosynthesis of other secondary metabolites; Biosynthesis of other bacterial compounds
Pathway
map00333  Prodigiosin biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
Compound
C00148  L-Proline
C12470  L-Prolyl-[pcp]
C12483  Pyrrole-2-carbonyl-[pcp]
C21567  Pyrrolyl-2-carboxyl-S-[acyl-carrier protein]
C21568  4-Hydroxy-2,2'-bipyrrole-5-methanol
C21569  4-Hydroxy-2,2'-bipyrrole-5-carbaldehyde
C21570  4-Methoxy-2,2'-bipyrrole-5-carbaldehyde
C21138  trans-2-Octenal
C21139  (S)-3-Acetyloctanal
C21571  2-Methyl-3-n-amyl-dihydropyrrole
C21572  2-Methyl-3-n-amyl-pyrrole
C21565  Prodigiosin
Reference
  Authors
Williamson NR, Simonsen HT, Ahmed RA, Goldet G, Slater H, Woodley L, Leeper FJ, Salmond GP
  Title
Biosynthesis of the red antibiotic, prodigiosin, in Serratia: identification of a novel 2-methyl-3-n-amyl-pyrrole (MAP) assembly pathway, definition of the terminal condensing enzyme, and implications for undecylprodigiosin biosynthesis in Streptomyces.
  Journal
Mol Microbiol 56:971-89 (2005)
DOI:10.1111/j.1365-2958.2005.04602.x

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