KEGG   MODULE: M00862
Entry
M00862            Pathway   Module                                 

Name
beta-Oxidation, peroxisome, tri/dihydroxycholestanoyl-CoA => choloyl/chenodeoxycholoyl-CoA
Definition
K10214 K12405 K08764
Diagram
M00862

Orthology
K10214  
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase [EC:1.17.99.3] [RN:R08735 R08740]
K12405  
(3R)-3-hydroxyacyl-CoA dehydrogenase / 3a,7a,12a-trihydroxy-5b-cholest-24-enoyl-CoA hydratase [EC:1.1.1.- 4.2.1.107] [RN:R04813 R04812 R04809 R04810]
K08764  
sterol carrier protein 2 [EC:2.3.1.176] [RN:R03719 R04811]
Class
Pathway modules; Lipid metabolism; Sterol biosynthesis
Pathway
map00120  Primary bile acid biosynthesis
map01100  Metabolic pathways
Reaction
Compound
C17343  (25S)-3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestan-26-oyl-CoA
C05460  (24E)-3alpha,7alpha,12alpha-Trihydroxy-5beta-cholest-24-enoyl-CoA
C15614  (24R,25R)-3alpha,7alpha,12alpha,24-Tetrahydroxy-5beta-cholestanoyl-CoA
C05467  3alpha,7alpha,12alpha-Trihydroxy-5beta-24-oxocholestanoyl-CoA
C01794  Choloyl-CoA
C17346  (25S)-3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA
C05447  (24E)-3alpha,7alpha-Dihydroxy-5beta-cholest-24-enoyl-CoA
C05448  (24R,25R)-3alpha,7alpha,24-Trihydroxy-5beta-cholestanoyl-CoA
C05449  3alpha,7alpha-Dihydroxy-5beta-24-oxocholestanoyl-CoA
C05337  Chenodeoxycholoyl-CoA
RModule
RM018  Beta oxidation in acyl-CoA degradation
Reference
  Authors
Waterham HR, Ferdinandusse S, Wanders RJ
  Title
Human disorders of peroxisome metabolism and biogenesis.
  Journal
Biochim Biophys Acta 1863:922-33 (2016)
DOI:10.1016/j.bbamcr.2015.11.015

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