KEGG   MODULE: M00867
Entry
M00867            Pathway   Module                                 

Name
KDO2-lipid A modification pathway
Definition
K12977 K03760 K23082+K23083 K23159 K09953
Diagram
M00867

Orthology
K12977  
lpxE; lipid A 1-phosphatase [EC:3.1.3.-] [RN:R12201]
K03760  
eptA; lipid A ethanolaminephosphotransferase [EC:2.7.8.43] [RN:R12202]
K23082  
kdoH1; 3-deoxy-D-manno-octulosonic acid-hydrolase [EC:3.2.1.144] [RN:R12219]
K23083  
kdoH2; 3-deoxy-D-manno-octulosonic acid-hydrolase [RN:R12219]
K23159  
lpxF; lipid A 4'-phosphatase [EC:3.1.3.-] [RN:R12203]
K09953  
lpxR; lipid A 3-O-deacylase [EC:3.1.1.-] [RN:R12204]
Class
Pathway modules; Glycan metabolism; Lipopolysaccharide metabolism
Pathway
map00540  Lipopolysaccharide biosynthesis
map01100  Metabolic pathways
Reaction
Compound
C21988  H. pylori KDO2-lipid A
C21994  1-Dephospho-KDO2-lipid A
C21995  1-PEtN-KDO2-lipid A
C21996  1-PEtN-KDO-lipid A
C21997  4'-Dephosphorylated 1-PEtN-KDO-lipid A
C21998  H. pylori KDO-lipid A
Reference
  Authors
Li H, Liao T, Debowski AW, Tang H, Nilsson HO, Stubbs KA, Marshall BJ, Benghezal M
  Title
Lipopolysaccharide Structure and Biosynthesis in Helicobacter pylori.
  Journal
Helicobacter 21:445-461 (2016)
DOI:10.1111/hel.12301
Reference
  Authors
Whitfield C, Trent MS
  Title
Biosynthesis and export of bacterial lipopolysaccharides.
  Journal
Annu Rev Biochem 83:99-128 (2014)
DOI:10.1146/annurev-biochem-060713-035600

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