KEGG   MODULE: M00868
Entry
M00868            Pathway   Module                                 
Name
Heme biosynthesis, animals and fungi, glycine => heme
Definition
K00643 K01698 K01749 K01719 K01599 K00228 K00231 K01772
Diagram
M00868

Orthology
K00643  
5-aminolevulinate synthase [EC:2.3.1.37] [RN:R00830]
K01698  
porphobilinogen synthase [EC:4.2.1.24] [RN:R00036]
K01749  
hydroxymethylbilane synthase [EC:2.5.1.61] [RN:R00084]
K01719  
uroporphyrinogen-III synthase [EC:4.2.1.75] [RN:R03165]
K01599  
uroporphyrinogen decarboxylase [EC:4.1.1.37] [RN:R03197]
K00228  
coproporphyrinogen III oxidase [EC:1.3.3.3] [RN:R03220]
K00231  
protoporphyrinogen/coproporphyrinogen III oxidase [EC:1.3.3.4] [RN:R03222]
K01772  
protoporphyrin/coproporphyrin ferrochelatase [EC:4.99.1.1] [RN:R00310]
Class
Pathway modules; Metabolism of cofactors and vitamins; Cofactor and vitamin metabolism
Pathway
map00860  Porphyrin metabolism
map01240  Biosynthesis of cofactors
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
Compound
C00037  Glycine
C00430  5-Aminolevulinate
C00931  Porphobilinogen
C01024  Hydroxymethylbilane
C01051  Uroporphyrinogen III
C03263  Coproporphyrinogen III
C01079  Protoporphyrinogen IX
C02191  Protoporphyrin
C00032  Heme
Reference
  Authors
Bryant DA, Hunter CN, Warren MJ
  Title
Biosynthesis of the modified tetrapyrroles-the pigments of life.
  Journal
J Biol Chem 295:6888-6925 (2020)
DOI:10.1074/jbc.REV120.006194

DBGET integrated database retrieval system