KEGG   MODULE: M00904
Entry
M00904            Pathway   Module                                 
Name
Dapdiamides biosynthesis, L-2,3-diaminopropanoate => dapdiamide A/B/C
Definition
K22113 K01957 K22114
Diagram
M00904

Orthology
K22113  
ddaG; fumarate---(S)-2,3-diaminopropanoate ligase [EC:6.3.2.46] [RN:R10940]
K01957  
ddaH; N-3-fumaroyl-(S)-2,3-diaminopropanoate amidotransferase [EC:6.3.5.-] [RN:R12352]
K22114  
ddaF; dapdiamide synthase [EC:6.3.2.47] [RN:R10942 R10943 R10944]
Class
Pathway modules; Biosynthesis of other secondary metabolites; Biosynthesis of other antibiotics
Pathway
map00998  Biosynthesis of various antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
Compound
C03401  L-2,3-Diaminopropanoate
C20961  N3-Fumaroyl-L-2,3-diaminopropanoate
C20966  3-{[(2E)-4-Amino-4-oxobut-2-enoyl]amino}-L-alanine
C20962  Dapdiamide A
C20963  Dapdiamide B
C20964  Dapdiamide C
Reference
  Authors
Hollenhorst MA, Clardy J, Walsh CT
  Title
The ATP-dependent amide ligases DdaG and DdaF assemble the fumaramoyl-dipeptide scaffold of the dapdiamide antibiotics.
  Journal
Biochemistry 48:10467-72 (2009)
DOI:10.1021/bi9013165

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