KEGG   MODULE: M00913
Entry
M00913            Pathway   Module                                 

Name
Pantothenate biosynthesis, 2-oxoisovalerate/spermine => pantothenate
Definition
K00606 K00077
K13367 K00128
K01918
Diagram
M00913

Orthology
K00606  
3-methyl-2-oxobutanoate hydroxymethyltransferase [EC:2.1.2.11] [RN:R01226]
K00077  
2-dehydropantoate 2-reductase [EC:1.1.1.169] [RN:R02472]
K13367  
polyamine oxidase [EC:1.5.3.17] [RN:R09076]
K00128  
aldehyde dehydrogenase (NAD+) [EC:1.2.1.3] [RN:R00904]
K01918  
pantoate--beta-alanine ligase [EC:6.3.2.1] [RN:R02473]
Class
Pathway modules; Metabolism of cofactors and vitamins; Cofactor and vitamin metabolism
Pathway
map00770  Pantothenate and CoA biosynthesis
map01240  Biosynthesis of cofactors
map01100  Metabolic pathways
Reaction
Compound
C00141  3-Methyl-2-oxobutanoic acid
C00966  2-Dehydropantoate
C00522  (R)-Pantoate
C00750  Spermine
C05665  3-Aminopropanal
C00099  beta-Alanine
C00864  Pantothenate
Reference
  Authors
White WH, Gunyuzlu PL, Toyn JH
  Title
Saccharomyces cerevisiae is capable of de Novo pantothenic acid biosynthesis involving a novel pathway of beta-alanine production from spermine.
  Journal
J Biol Chem 276:10794-800 (2001)
DOI:10.1074/jbc.M009804200
Reference
  Authors
White WH, Skatrud PL, Xue Z, Toyn JH
  Title
Specialization of function among aldehyde dehydrogenases: the ALD2 and ALD3 genes are required for beta-alanine biosynthesis in Saccharomyces cerevisiae.
  Journal
Genetics 163:69-77 (2003)

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