KEGG   NETWORK: N00459
Entry
N00459                      Network                                

Name
WEE1-Cell cycle G2/M
Definition
ATR -> CHEK1 -> WEE1 -| (CCNB+CDK1)
  Expanded
545 -> 1111 -> 7465 -| ((891,9133,85417)+983)
Class
nt06130 Cell cycle (viruses)
nt06161 Human immunodeficiency virus type 1 (HIV-1)
Type
Reference
Pathway
hsa04110  Cell cycle
Gene
545  ATR; ATR serine/threonine kinase
1111  CHEK1; checkpoint kinase 1
7465  WEE1; WEE1 G2 checkpoint kinase
891  CCNB1; cyclin B1
9133  CCNB2; cyclin B2
85417  CCNB3; cyclin B3
983  CDK1; cyclin dependent kinase 1
Reference
  Authors
Rhind N, Russell P
  Title
Signaling pathways that regulate cell division.
  Journal
Cold Spring Harb Perspect Biol 4:a005942 (2012)
DOI:10.1101/cshperspect.a005942
Reference
  Authors
Shaltiel IA, Krenning L, Bruinsma W, Medema RH
  Title
The same, only different - DNA damage checkpoints and their reversal throughout the cell cycle.
  Journal
J Cell Sci 128:607-20 (2015)
DOI:10.1242/jcs.163766
Reference
  Authors
Wang Y, Ji P, Liu J, Broaddus RR, Xue F, Zhang W
  Title
Centrosome-associated regulators of the G(2)/M checkpoint as targets for cancer therapy.
  Journal
Mol Cancer 8:8 (2009)
DOI:10.1186/1476-4598-8-8
Reference
  Authors
Matheson CJ, Backos DS, Reigan P
  Title
Targeting WEE1 Kinase in Cancer.
  Journal
Trends Pharmacol Sci 37:872-881 (2016)
DOI:10.1016/j.tips.2016.06.006

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