Entry |
|
Name |
HTLV-1 p12 to Jak-STAT signaling pathway
|
Definition |
P12 -> IL2RB/G -> JAK1/3 -> STAT5 => IL2 |
Expanded |
K23069 -> (3560,3561) -> (3716,3718) -> (6776,6777) => 3558 |
Class |
nt06518 JAK-STAT signaling
nt06150 Cytokine-cytokine receptor interaction (viruses)
nt06219 JAK-STAT signaling
nt06160 Human T-cell leukemia virus 1 (HTLV-1)
|
Type |
Pathogen
|
Pathway |
hsa05166 | Human T-cell leukemia virus 1 infection |
hsa04061 | Viral protein interaction with cytokine and cytokine receptor |
|
Disease |
|
Gene |
3560 | IL2RB; interleukin 2 receptor subunit beta |
3561 | IL2RG; interleukin 2 receptor subunit gamma |
3716 | JAK1; Janus kinase 1 |
3718 | JAK3; Janus kinase 3 |
6776 | STAT5A; signal transducer and activator of transcription 5A |
6777 | STAT5B; signal transducer and activator of transcription 5B |
|
Perturbant |
K23069 (P12) | p12I; HTLV-1 accessory protein p12I |
|
Reference |
|
Authors |
Sinet F. |
Title |
Complex splicing in the human T-cell leukemia virus (HTLV) family of retroviruses: a number of proteins play a key role in the establishment and maintenance of viral infection. |
Journal |
BioSciences Master Reviews, July 2013 |
Reference |
|
Authors |
Bai XT, Nicot C |
Title |
Overview on HTLV-1 p12, p8, p30, p13: accomplices in persistent infection and viral pathogenesis. |
Journal |
|
Reference |
|
Authors |
Nicot C, Mulloy JC, Ferrari MG, Johnson JM, Fu K, Fukumoto R, Trovato R, Fullen J, Leonard WJ, Franchini G |
Title |
HTLV-1 p12(I) protein enhances STAT5 activation and decreases the interleukin-2 requirement for proliferation of primary human peripheral blood mononuclear cells. |
Journal |
|
Reference |
|
Authors |
Taylor JM, Nicot C |
Title |
HTLV-1 and apoptosis: role in cellular transformation and recent advances in therapeutic approaches. |
Journal |
|