KEGG   NETWORK: N00548
Entry
N00548                      Network                                
Name
HBV HBx to Jak-STAT signaling pathway
Definition
X -> STAT3
  Expanded
K21854 -> 6774
Class
nt06518 JAK-STAT signaling
nt06263 Hepatocellular carcinoma
nt06162 Hepatitis B virus (HBV)
Type
Pathogen
Pathway
hsa05161  Hepatitis B
Disease
H00048  Hepatocellular carcinoma
Gene
6774  STAT3; signal transducer and activator of transcription 3
Perturbant
K21854 (X)  X; HBV protein X
Reference
PMID:11604508
  Authors
Waris G, Huh KW, Siddiqui A
  Title
Mitochondrially associated hepatitis B virus X protein constitutively activates transcription factors STAT-3 and NF-kappa B via oxidative stress.
  Journal
Mol Cell Biol 21:7721-30 (2001)
DOI:10.1128/MCB.21.22.7721-7730.2001
Reference
PMID:12686421
  Authors
Panteva M, Korkaya H, Jameel S
  Title
Hepatitis viruses and the MAPK pathway: is this a survival strategy?
  Journal
Virus Res 92:131-40 (2003)
DOI:10.1016/S0168-1702(02)00356-8
Reference
PMID:9738022
  Authors
Lee YH, Yun Y
  Title
HBx protein of hepatitis B virus activates Jak1-STAT signaling.
  Journal
J Biol Chem 273:25510-5 (1998)
DOI:10.1074/jbc.273.39.25510

  All links  
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (1)   
   KEGG DISEASE (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
Literature (3)   
   PubMed (3)   
All databases (7)   

Download RDF
DBGET integrated database retrieval system