KEGG   NETWORK: N01362
Entry
N01362                      Network                                

Name
Nuclear-initiated progesterone signaling pathway
Definition
P4 -> PGR => (CCND1,TNFSF11,WNT4,CXCL12)
  Expanded
C00410 -> 5241 => (595,8600,54361,6387)
Class
nt06227 Nuclear receptor signaling
Type
Reference
Gene
5241  PGR; progesterone receptor
595  CCND1; cyclin D1
8600  TNFSF11; TNF superfamily member 11
54361  WNT4; Wnt family member 4
6387  CXCL12; C-X-C motif chemokine ligand 12
Metabolite
C00410  Progesterone
Reference
  Authors
Grimm SL, Hartig SM, Edwards DP
  Title
Progesterone Receptor Signaling Mechanisms.
  Journal
J Mol Biol 428:3831-49 (2016)
DOI:10.1016/j.jmb.2016.06.020
Reference
  Authors
Cenciarini ME, Proietti CJ
  Title
Molecular mechanisms underlying progesterone receptor action in breast cancer: Insights into cell proliferation and stem cell regulation.
  Journal
Steroids 152:108503 (2019)
DOI:10.1016/j.steroids.2019.108503
Reference
  Authors
Obr AE, Edwards DP
  Title
The biology of progesterone receptor in the normal mammary gland and in breast cancer.
  Journal
Mol Cell Endocrinol 357:4-17 (2012)
DOI:10.1016/j.mce.2011.10.030

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