KEGG   NETWORK: N01363
Entry
N01363                      Network                                

Name
P4/MPA to nuclear-initiated progesterone signaling pathway
Definition
(P4,MPA) -> PGR => (WNT1,NOTCH2,JAG1)
  Expanded
(C00410,C08150) -> 5241 => (7471,4853,182)
Class
nt06227 Nuclear receptor signaling
Type
Env factor
Pathway
hsa05207  Chemical carcinogenesis - receptor activation
Disease
H00031  Breast cancer
Gene
5241  PGR; progesterone receptor
7471  WNT1; Wnt family member 1
4853  NOTCH2; notch receptor 2
182  JAG1; jagged canonical Notch ligand 1
Perturbant
C00410 (P4)  Progesterone
C08150 (MPA)  Medroxyprogesterone acetate
Reference
  Authors
Pedroza DA, Subramani R, Lakshmanaswamy R
  Title
Classical and Non-Classical Progesterone Signaling in Breast Cancers.
  Journal
Cancers (Basel) 12:E2440 (2020)
DOI:10.3390/cancers12092440
Reference
  Authors
Finlay-Schultz J, Sartorius CA
  Title
Steroid hormones, steroid receptors, and breast cancer stem cells.
  Journal
J Mammary Gland Biol Neoplasia 20:39-50 (2015)
DOI:10.1007/s10911-015-9340-5
Reference
  Authors
Chen B, Ye P, Chen Y, Liu T, Cha JH, Yan X, Yang WH
  Title
Involvement of the Estrogen and Progesterone Axis in Cancer Stemness: Elucidating Molecular Mechanisms and Clinical Significance.
  Journal
Front Oncol 10:1657 (2020)
DOI:10.3389/fonc.2020.01657
Reference
  Authors
Asi N, Mohammed K, Haydour Q, Gionfriddo MR, Vargas OL, Prokop LJ, Faubion SS, Murad MH
  Title
Progesterone vs. synthetic progestins and the risk of breast cancer: a systematic review and meta-analysis.
  Journal
Syst Rev 5:121 (2016)
DOI:10.1186/s13643-016-0294-5

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