KEGG   NETWORK: N01364
Entry
N01364                      Network                                

Name
E2 to nuclear-initiated estrogen signaling pathway
Definition
E2 -> ESR1/2 => (EGF,FGF9,DLL)
  Expanded
C00951 -> (2099,2100) => (1950,2254,28514,10683,54567)
Class
nt06227 Nuclear receptor signaling
Type
Env factor
Pathway
hsa05207  Chemical carcinogenesis - receptor activation
Disease
H00031  Breast cancer
Gene
2099  ESR1; estrogen receptor 1
2100  ESR2; estrogen receptor 2
1950  EGF; epidermal growth factor
2254  FGF9; fibroblast growth factor 9
28514  DLL1; delta like canonical Notch ligand 1
10683  DLL3; delta like canonical Notch ligand 3
54567  DLL4; delta like canonical Notch ligand 4
Perturbant
C00951 (E2)  Estradiol-17beta
Reference
  Authors
Finlay-Schultz J, Sartorius CA
  Title
Steroid hormones, steroid receptors, and breast cancer stem cells.
  Journal
J Mammary Gland Biol Neoplasia 20:39-50 (2015)
DOI:10.1007/s10911-015-9340-5
Reference
  Authors
Chen B, Ye P, Chen Y, Liu T, Cha JH, Yan X, Yang WH
  Title
Involvement of the Estrogen and Progesterone Axis in Cancer Stemness: Elucidating Molecular Mechanisms and Clinical Significance.
  Journal
Front Oncol 10:1657 (2020)
DOI:10.3389/fonc.2020.01657
Reference
  Authors
Harrison H, Simoes BM, Rogerson L, Howell SJ, Landberg G, Clarke RB
  Title
Oestrogen increases the activity of oestrogen receptor negative breast cancer stem cells through paracrine EGFR and Notch signalling.
  Journal
Breast Cancer Res 15:R21 (2013)
DOI:10.1186/bcr3396
Reference
  Authors
Mallepell S, Krust A, Chambon P, Brisken C
  Title
Paracrine signaling through the epithelial estrogen receptor alpha is required for proliferation and morphogenesis in the mammary gland.
  Journal
Proc Natl Acad Sci U S A 103:2196-201 (2006)
DOI:10.1073/pnas.0510974103

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