KEGG   NETWORK: N01411
Entry
N01411                      Network                                
Name
Metals to NFKB signaling pathway
Definition
Metals -> ROS -| PTP -| SRC -> ABL -> PKD -> IKK -> NFKBIA -> NFKB
  Expanded
(C06269,C01413,C19171,C06268,C06696,C00023,C00291) -> C22381 -| (52,5781,5795) -| 6714 -> (25,27) -> (23683,25865,5587) -> (1147+3551+8517) -> 4792 -> (4790+5970)
Class
nt06223 TNF signaling
Type
Env factor
Pathway
hsa05208  Chemical carcinogenesis - reactive oxygen species
Disease
H00021  Renal cell carcinoma
H00024  Prostate cancer
H00014  Non-small cell lung cancer
H00013  Small cell lung cancer
H00048  Hepatocellular carcinoma
H00054  Nasopharyngeal cancer
Gene
52  ACP1; acid phosphatase 1
5781  PTPN11; protein tyrosine phosphatase non-receptor type 11
5795  PTPRJ; protein tyrosine phosphatase receptor type J
6714  SRC; SRC proto-oncogene, non-receptor tyrosine kinase
25  ABL1; ABL proto-oncogene 1, non-receptor tyrosine kinase
27  ABL2; ABL proto-oncogene 2, non-receptor tyrosine kinase
23683  PRKD3; protein kinase D3
25865  PRKD2; protein kinase D2
5587  PRKD1; protein kinase D1
1147  CHUK; component of inhibitor of nuclear factor kappa B kinase complex
3551  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta
8517  IKBKG; inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
4792  NFKBIA; NFKB inhibitor alpha
4790  NFKB1; nuclear factor kappa B subunit 1
5970  RELA; RELA proto-oncogene, NF-kB subunit
Perturbant
C06269 (Metals)  Arsenic
C01413 (Metals)  Cadmium
C19171 (Metals)  Cobalt
C06268 (Metals)  Chromium
C06696 (Metals)  Lead
C00023 (Metals)  Iron
C00291 (Metals)  Nickel
Metabolite
C22381  Reactive oxygen species
Reference
  Authors
Storz P
  Title
Reactive oxygen species in tumor progression.
  Journal
Front Biosci 10:1881-96 (2005)
DOI:10.2741/1667
Reference
  Authors
Liou GY, Storz P
  Title
Reactive oxygen species in cancer.
  Journal
Free Radic Res 44:479-96 (2010)
DOI:10.3109/10715761003667554
Reference
  Authors
Storz P, Doppler H, Toker A
  Title
Protein kinase Cdelta selectively regulates protein kinase D-dependent activation of NF-kappaB in oxidative stress signaling.
  Journal
Mol Cell Biol 24:2614-26 (2004)
DOI:10.1128/MCB.24.7.2614-2626.2004

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