KEGG   NETWORK: N01431
Entry
N01431                      Network                                
Name
Core NER reaction
Definition
(ERCC3+ERCC2+GTF2H) == ERCC5 == XPA == RPA -> (ERCC1+ERCC4) == XPA == RPA == ERCC5 -> PCNA == POLD,POLE,POLK,POLH -> LIG1,(LIG3+XRCC1)
  Expanded
(2071+2068+2965+2966+2967+2968+404672) == 2073 == 7507 == (6117+6118+6119+29935) -> (2067+2072) == 7507 == (6117+6118+6119+29935) == 2073 -> 5111 == (5424+5425+10714+57804),(5426+5427+54107+56655),51426,5429 -> 3978,(3980+7515)
Class
nt06502 Nucleotide excision repair
Type
Reference
Pathway
hsa03420  Nucleotide excision repair
Gene
2071  ERCC3; ERCC excision repair 3, TFIIH core complex helicase subunit
2068  ERCC2; ERCC excision repair 2, TFIIH core complex helicase subunit
2965  GTF2H1; general transcription factor IIH subunit 1
2966  GTF2H2; general transcription factor IIH subunit 2
2967  GTF2H3; general transcription factor IIH subunit 3
2968  GTF2H4; general transcription factor IIH subunit 4
404672  GTF2H5; general transcription factor IIH subunit 5
2073  ERCC5; ERCC excision repair 5, endonuclease
7507  XPA; XPA, DNA damage recognition and repair factor
6117  RPA1; replication protein A1
6118  RPA2; replication protein A2
6119  RPA3; replication protein A3
29935  RPA4; replication protein A4
2067  ERCC1; ERCC excision repair 1, endonuclease non-catalytic subunit
2072  ERCC4; ERCC excision repair 4, endonuclease catalytic subunit
5111  PCNA; proliferating cell nuclear antigen
5424  POLD1; DNA polymerase delta 1, catalytic subunit
5425  POLD2; DNA polymerase delta 2, accessory subunit
10714  POLD3; DNA polymerase delta 3, accessory subunit
57804  POLD4; DNA polymerase delta 4, accessory subunit
5426  POLE; DNA polymerase epsilon, catalytic subunit
5427  POLE2; DNA polymerase epsilon 2, accessory subunit
54107  POLE3; DNA polymerase epsilon 3, accessory subunit
56655  POLE4; DNA polymerase epsilon 4, accessory subunit
51426  POLK; DNA polymerase kappa
5429  POLH; DNA polymerase eta
3978  LIG1; DNA ligase 1
3980  LIG3; DNA ligase 3
7515  XRCC1; X-ray repair cross complementing 1
Reference
  Authors
Marteijn JA, Lans H, Vermeulen W, Hoeijmakers JH
  Title
Understanding nucleotide excision repair and its roles in cancer and ageing.
  Journal
Nat Rev Mol Cell Biol 15:465-81 (2014)
DOI:10.1038/nrm3822
Reference
  Authors
Krasikova Y, Rechkunova N, Lavrik O
  Title
Nucleotide Excision Repair: From Molecular Defects to Neurological Abnormalities.
  Journal
Int J Mol Sci 22:6220 (2021)
DOI:10.3390/ijms22126220

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