N01432                      Network                                
Mismatch repair
(MSH2+MSH6,MSH3) == (MLH1+PMS2,PMS1,MLH3) == PCNA == RFC -> RPA == EXO1 -> POLD,POLE -> LIG1
(4436+2956,4437) == (4292+5395,5378,27030) == 5111 == (5981+5982+5983+5984+5985) -> (6117+6118+6119) == 9156 -> (5424+5425+10714+57804),(5426+5427+54107+56655) -> 3978
nt06503 Mismatch repair
hsa03430  Mismatch repair
4436  MSH2; mutS homolog 2
2956  MSH6; mutS homolog 6
4437  MSH3; mutS homolog 3
4292  MLH1; mutL homolog 1
5395  PMS2; PMS1 homolog 2, mismatch repair system component
5378  PMS1; PMS1 homolog 1, mismatch repair system component
27030  MLH3; mutL homolog 3
5111  PCNA; proliferating cell nuclear antigen
5981  RFC1; replication factor C subunit 1
5982  RFC2; replication factor C subunit 2
5983  RFC3; replication factor C subunit 3
5984  RFC4; replication factor C subunit 4
5985  RFC5; replication factor C subunit 5
6117  RPA1; replication protein A1
6118  RPA2; replication protein A2
6119  RPA3; replication protein A3
9156  EXO1; exonuclease 1
5424  POLD1; DNA polymerase delta 1, catalytic subunit
5425  POLD2; DNA polymerase delta 2, accessory subunit
10714  POLD3; DNA polymerase delta 3, accessory subunit
57804  POLD4; DNA polymerase delta 4, accessory subunit
5426  POLE; DNA polymerase epsilon, catalytic subunit
5427  POLE2; DNA polymerase epsilon 2, accessory subunit
54107  POLE3; DNA polymerase epsilon 3, accessory subunit
56655  POLE4; DNA polymerase epsilon 4, accessory subunit
3978  LIG1; DNA ligase 1
Rahimian E, Amini A, Alikarami F, Pezeshki SMS, Saki N, Safa M
DNA repair pathways as guardians of the genome: Therapeutic potential and possible prognostic role in hematologic neoplasms.
DNA Repair (Amst) 96:102951 (2020)
Pannafino G, Alani E
Coordinated and Independent Roles for MLH Subunits in DNA Repair.
Cells 10:948 (2021)
Xavier A, Olsen MF, Lavik LA, Johansen J, Singh AK, Sjursen W, Scott RJ, Talseth-Palmer BA
Comprehensive mismatch repair gene panel identifies variants in patients with Lynch-like syndrome.
Mol Genet Genomic Med 7:e850 (2019)
Chung J, Maruvka YE, Sudhaman S, Kelly J, Haradhvala NJ, Bianchi V, Edwards M, Forster VJ, Nunes NM, Galati MA, Komosa M, Deshmukh S, Cabric V, Davidson S, Zatzman M, Light N, Hayes R, Brunga L, Anderson ND, Ho B, Hodel KP, Siddaway R, Morrissy AS, Bowers DC, Larouche V, Bronsema A, Osborn M, Cole KA, Opocher E, Mason G, Thomas GA, George B, Ziegler DS, Lindhorst S, Vanan M, Yalon-Oren M, Reddy AT, Massimino M, Tomboc P, Van Damme A, Lossos A, Durno C, Aronson M, Morgenstern DA, Bouffet E, Huang A, Taylor MD, Villani A, Malkin D, Hawkins CE, Pursell ZF, Shlien A, Kunkel TA, Getz G, Tabori U
DNA Polymerase and Mismatch Repair Exert Distinct Microsatellite Instability Signatures in Normal and Malignant Human Cells.
Cancer Discov 11:1176-1191 (2021)

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