KEGG   REACTION: R00238
Entry
R00238                      Reaction                               
Name
acetyl-CoA:acetyl-CoA C-acetyltransferase
Definition
2 Acetyl-CoA <=> CoA + Acetoacetyl-CoA
Equation
2 C00024 <=> C00010 + C00332
Reaction class
RC00004  C00010_C00024
RC00326  C00024_C00332
Enzyme
2.3.1.9         2.3.1.16
Pathway
rn00071  Fatty acid degradation
rn00280  Valine, leucine and isoleucine degradation
rn00310  Lysine degradation
rn00362  Benzoate degradation
rn00380  Tryptophan metabolism
rn00620  Pyruvate metabolism
rn00630  Glyoxylate and dicarboxylate metabolism
rn00650  Butanoate metabolism
rn00720  Carbon fixation pathways in prokaryotes
rn00900  Terpenoid backbone biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
rn01212  Fatty acid metabolism
Module
M00087  beta-Oxidation
M00088  Ketone body biosynthesis, acetyl-CoA => acetoacetate/3-hydroxybutyrate/acetone
M00095  C5 isoprenoid biosynthesis, mevalonate pathway
M00373  Ethylmalonyl pathway
M00374  Dicarboxylate-hydroxybutyrate cycle
M00375  Hydroxypropionate-hydroxybutylate cycle
M00849  C5 isoprenoid biosynthesis, mevalonate pathway, archaea
Orthology
K00626  acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
K00632  acetyl-CoA acyltransferase [EC:2.3.1.16]
K07508  acetyl-CoA acyltransferase 2 [EC:2.3.1.16]
K07509  acetyl-CoA acyltransferase [EC:2.3.1.16]
K07513  acetyl-CoA acyltransferase 1 [EC:2.3.1.16]
Reference
1  [PMID:25478839]
  Authors
Kiema TR, Harijan RK, Strozyk M, Fukao T, Alexson SE, Wierenga RK.
  Title
The crystal structure of human mitochondrial 3-ketoacyl-CoA thiolase (T1): insight into the reaction mechanism of its thiolase and thioesterase activities.
  Journal
Acta Crystallogr D Biol Crystallogr 70:3212-25 (2014)
DOI:10.1107/S1399004714023827
Reference
2  [PMID:12535077]
  Authors
Campbell JW, Morgan-Kiss RM, Cronan JE Jr
  Title
A new Escherichia coli metabolic competency: growth on fatty acids by a novel anaerobic beta-oxidation pathway.
  Journal
Mol Microbiol 47:793-805 (2003)
DOI:10.1046/j.1365-2958.2003.03341.x
Reference
3  [PMID:22669882]
  Authors
Hu J, Baker A, Bartel B, Linka N, Mullen RT, Reumann S, Zolman BK.
  Title
Plant peroxisomes: biogenesis and function.
  Journal
Plant Cell 24:2279-303 (2012)
DOI:10.1105/tpc.112.096586
Other DBs
RHEA: 21039

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (37)   
   KEGG PATHWAY (30)   
   KEGG MODULE (7)   
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (6)   
   KEGG ENZYME (2)   
   KEGG RCLASS (2)   
   SABIO-RK (1)   
   UMBBD-RN (1)   
Gene (28848)   
   KEGG ORTHOLOGY (5)   
   KEGG GENES (28843)   
All databases (28896)   

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KEGG   RCLASS: RC00326
Entry
RC00326                     RClass                                 
Definition
C1a-C1b:*-C5a:C5a-C5a
Reactant pair
C00022_C02119    C00022_C02132    C00022_C02167
C00022_C02514    C00022_C05406    C00022_C20781
C00024_C00264    C00024_C00332    C00024_C02232
C00024_C05259    C00024_C05261    C00024_C05263
C00024_C05265    C00024_C05267    C00024_C05269
C00024_C06715    C00024_C07118    C00024_C16330
C00024_C16334    C00024_C16338    C00024_C16376
C00024_C16389    C00024_C16466    C00024_C16471
C00024_C19945    C00164_C01061    C01949_C02445
Related class
Reaction
R00238 R00324 R00391 R00543 R00829 R01085 R01177 R01335
R01364 R03778 R03781 R03858 R03991 R04742 R04747 R05506
R05586 R07891 R07895 R07899 R07937 R07953 R08091 R08095
R09839 R10691 R11257
Enzyme
2.3.1.9         2.3.1.16        2.3.1.155       2.3.1.174       
2.3.1.176       2.3.1.223       2.3.1.-         3.7.1.2         
3.7.1.5         3.7.1.6         3.7.1.7         3.7.1.20        
3.7.1.23        3.7.1.26        3.7.1.-
Pathway
rn00062  Fatty acid elongation
rn00071  Fatty acid degradation
rn00280  Valine, leucine and isoleucine degradation
rn00310  Lysine degradation
rn00350  Tyrosine metabolism
rn00360  Phenylalanine metabolism
rn00362  Benzoate degradation
rn00380  Tryptophan metabolism
rn00620  Pyruvate metabolism
rn00630  Glyoxylate and dicarboxylate metabolism
rn00642  Ethylbenzene degradation
rn00643  Styrene degradation
rn00650  Butanoate metabolism
rn00720  Carbon fixation pathways in prokaryotes
rn00900  Terpenoid backbone biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
rn01212  Fatty acid metabolism
rn01220  Degradation of aromatic compounds
RModule
RM018  Beta oxidation in acyl-CoA degradation
RM020  Fatty acid synthesis using acetyl-CoA (reversal of RM018)
Orthology
K00626  acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
K00632  acetyl-CoA acyltransferase [EC:2.3.1.16]
K01555  fumarylacetoacetase [EC:3.7.1.2]
K01557  acylpyruvate hydrolase [EC:3.7.1.5]
K02615  3-oxo-5,6-didehydrosuberyl-CoA/3-oxoadipyl-CoA thiolase [EC:2.3.1.223 2.3.1.174]
K07508  acetyl-CoA acyltransferase 2 [EC:2.3.1.16]
K07509  acetyl-CoA acyltransferase [EC:2.3.1.16]
K07513  acetyl-CoA acyltransferase 1 [EC:2.3.1.16]
K07823  3-oxoadipyl-CoA thiolase [EC:2.3.1.174]
K08764  sterol carrier protein 2 [EC:2.3.1.176]
K15866  2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase [EC:5.3.3.18]
K16164  acylpyruvate hydrolase [EC:3.7.1.5]
K16165  fumarylpyruvate hydrolase [EC:3.7.1.20]
K16171  fumarylacetoacetate (FAA) hydrolase [EC:3.7.1.2]
K18336  2,4-didehydro-3-deoxy-L-rhamnonate hydrolase [EC:3.7.1.26]
K20758  maleylpyruvate hydrolase [EC:3.7.1.23]

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Pathway (21)   
   KEGG PATHWAY (21)   
Chemical reaction (46)   
   KEGG ENZYME (13)   
   KEGG REACTION (27)   
   UMBBD-BT (6)   
Gene (16)   
   KEGG ORTHOLOGY (16)   
All databases (83)   

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