KEGG   REACTION: R01840
Entry
R01840                      Reaction                               

Name
androstenedione,NADPH---hemoprotein reductase:oxygen oxidoreductase (19-hydroxylating)
Definition
Androstenedione + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> 19-Hydroxyandrost-4-ene-3,17-dione + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
Comment
aromatase, ARO
three successive reactions (R01840+R04759+R02351)
subsequently R04759
Reaction class
RC00257  C00280_C05290
Enzyme
Pathway
rn00140  Steroid hormone biosynthesis
rn01100  Metabolic pathways
Module
M00110  C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
Orthology
K07434  aromatase [EC:1.14.14.14]
Other DBs
RHEA: 38202

KEGG   RCLASS: RC00257
Entry
RC00257                     RClass                                 

Definition
C1a-C1b:*-O1a:C1z-C1z
Reactant pair
Related class
Reaction
Enzyme
1.14.11.12      1.14.13.246     1.14.13.-       1.14.14.14      
1.14.14.67      1.14.14.86      1.14.14.111     1.14.14.115     
1.14.14.126     1.14.14.134     1.14.14.137     1.14.14.144     
1.14.14.154     1.14.14.-       1.14.15.4       1.14.15.5       
1.14.15.36      1.14.18.9       1.14.18.10
Pathway
rn00140  Steroid hormone biosynthesis
rn00904  Diterpenoid biosynthesis
rn00906  Carotenoid biosynthesis
rn00909  Sesquiterpenoid and triterpenoid biosynthesis
rn00981  Insect hormone biosynthesis
rn00996  Biosynthesis of various alkaloids
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K04122  ent-kaurene oxidase [EC:1.14.14.86]
K05282  gibberellin-44 dioxygenase [EC:1.14.11.12]
K07433  steroid 11beta-monooxygenase / corticosterone 18-monooxygenase [EC:1.14.15.4 1.14.15.5]
K07434  aromatase [EC:1.14.14.14]
K09843  (+)-abscisic acid 8'-hydroxylase [EC:1.14.14.137]
K12918  cytochrome P450 monooxygenase 2
K15814  beta-amyrin 24-hydroxylase [EC:1.14.14.134]
K15826  sesquiterpenoid omega-hydroxylase
K21292  ent-kaurene oxidase [EC:1.14.14.86]
K22637  11-hydroxysugiol 20-monooxygenase [EC:1.14.14.67]
K25486  cucurbitadienol 19-hydroxylase [EC:1.14.14.-]

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