KEGG   REACTION: R02101
Entry
R02101                      Reaction                               
Name
5,10-Methylenetetrahydrofolate:dUMP C-methyltransferase
Definition
dUMP + 5,10-Methylenetetrahydrofolate <=> Dihydrofolate + dTMP
Equation
C00365 + C00143 <=> C00415 + C00364
Reaction class
RC00219  C00143_C00415
RC00332  C00364_C00365
Enzyme
2.1.1.45
Pathway
rn00240  Pyrimidine metabolism
rn00670  One carbon pool by folate
rn01100  Metabolic pathways
rn01232  Nucleotide metabolism
Module
M00938  Pyrimidine deoxyribonucleotide biosynthesis, UDP => dTTP
Orthology
K00560  thymidylate synthase [EC:2.1.1.45]
K13998  dihydrofolate reductase / thymidylate synthase [EC:1.5.1.3 2.1.1.45]
Other DBs
RHEA: 12107

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Ontology (1)   
   KEGG BRITE (1)   
Pathway (9)   
   KEGG PATHWAY (8)   
   KEGG MODULE (1)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG RCLASS (2)   
   SABIO-RK (1)   
Gene (7025)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (7023)   
All databases (7043)   

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KEGG   RCLASS: RC00219
Entry
RC00219                     RClass                                 
Definition
C1y-C2y:*-*:C1x+C1x+N1y-C1b+C1x+N2x
N1y-N1b:C1x-*:C1x+C8y-C1b+C8y
N1y-N2x:C1x-*:C1y+C8y-C2y+C8y
Reactant pair
C00143_C00415
Related class
Reaction
R01670 R02101
Enzyme
2.1.1.45        2.1.1.54
Pathway
rn00670  One carbon pool by folate
rn01100  Metabolic pathways
Orthology
K00560  thymidylate synthase [EC:2.1.1.45]
K13998  dihydrofolate reductase / thymidylate synthase [EC:1.5.1.3 2.1.1.45]

  All links  
Pathway (2)   
   KEGG PATHWAY (2)   
Chemical reaction (4)   
   KEGG ENZYME (2)   
   KEGG REACTION (2)   
Gene (2)   
   KEGG ORTHOLOGY (2)   
All databases (8)   

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KEGG   RCLASS: RC00332
Entry
RC00332                     RClass                                 
Definition
C8x-C8y:*-C1a:C8x+C8y-C8x+C8y
Reactant pair
C00082_C20800    C00239_C03495    C00364_C00365
C00632_C03986    C00828_C22027    C00856_C02967
C01764_C03446    C04155_C17325    C05818_C22028
C21312_C21313    C22450_C22451
Related class
Reaction
R00594 R00595 R01670 R02101 R02667 R03704 R04858 R06613
R10964 R11371 R12238 R12239 R12548 R12855
Enzyme
2.1.1.35        2.1.1.37        2.1.1.45        2.1.1.54        
2.1.1.74        2.1.1.97        2.1.1.148       2.1.1.202       
2.1.1.203       2.1.1.204       2.1.1.304       2.1.1.350       
2.1.1.-
Pathway
rn00240  Pyrimidine metabolism
rn00860  Porphyrin metabolism
rn01059  Biosynthesis of enediyne antibiotics
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01232  Nucleotide metabolism
Orthology
K00558  DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
K00560  thymidylate synthase [EC:2.1.1.45]
K03465  thymidylate synthase (FAD) [EC:2.1.1.148]
K13998  dihydrofolate reductase / thymidylate synthase [EC:1.5.1.3 2.1.1.45]
K17398  DNA (cytosine-5)-methyltransferase 3A [EC:2.1.1.37]
K17399  DNA (cytosine-5)-methyltransferase 3B [EC:2.1.1.37]
K21192  methyltransferase [EC:2.1.1.-]
K23078  menaquinone C8-methyltransferase [EC:2.1.1.350]
K25498  5-methoxybenzimidazole methyltransferase

  All links  
Pathway (6)   
   KEGG PATHWAY (6)   
Chemical reaction (26)   
   KEGG ENZYME (12)   
   KEGG REACTION (14)   
Gene (9)   
   KEGG ORTHOLOGY (9)   
All databases (41)   

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