KEGG   REACTION: R02101
Entry
R02101                      Reaction                               

Name
5,10-Methylenetetrahydrofolate:dUMP C-methyltransferase
Definition
dUMP + 5,10-Methylenetetrahydrofolate <=> Dihydrofolate + dTMP
Equation
Reaction class
RC00219  C00143_C00415
RC00332  C00364_C00365
Enzyme
Pathway
rn00240  Pyrimidine metabolism
rn00670  One carbon pool by folate
rn01100  Metabolic pathways
Module
M00938  Pyrimidine deoxyribonuleotide biosynthesis, UDP => dTTP
Orthology
K00560  thymidylate synthase [EC:2.1.1.45]
K13998  dihydrofolate reductase / thymidylate synthase [EC:1.5.1.3 2.1.1.45]
Other DBs
RHEA: 12107

KEGG   RCLASS: RC00219
Entry
RC00219                     RClass                                 

Definition
C1y-C2y:*-*:C1x+C1x+N1y-C1b+C1x+N2x
N1y-N1b:C1x-*:C1x+C8y-C1b+C8y
N1y-N2x:C1x-*:C1y+C8y-C2y+C8y
Reactant pair
Related class
Reaction
Enzyme
2.1.1.45        2.1.1.54
Pathway
rn00670  One carbon pool by folate
rn01100  Metabolic pathways
Orthology
K00560  thymidylate synthase [EC:2.1.1.45]
K13998  dihydrofolate reductase / thymidylate synthase [EC:1.5.1.3 2.1.1.45]

KEGG   RCLASS: RC00332
Entry
RC00332                     RClass                                 

Definition
C8x-C8y:*-C1a:C8x+C8y-C8x+C8y
Reactant pair
Related class
Reaction
Enzyme
2.1.1.35        2.1.1.37        2.1.1.45        2.1.1.54        
2.1.1.74        2.1.1.97        2.1.1.148       2.1.1.202       
2.1.1.203       2.1.1.204       2.1.1.304       2.1.1.350       
2.1.1.-
Pathway
rn00240  Pyrimidine metabolism
rn00860  Porphyrin metabolism
rn01059  Biosynthesis of enediyne antibiotics
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K00558  DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
K00560  thymidylate synthase [EC:2.1.1.45]
K03465  thymidylate synthase (FAD) [EC:2.1.1.148]
K13998  dihydrofolate reductase / thymidylate synthase [EC:1.5.1.3 2.1.1.45]
K17398  DNA (cytosine-5)-methyltransferase 3A [EC:2.1.1.37]
K17399  DNA (cytosine-5)-methyltransferase 3B [EC:2.1.1.37]
K21192  methyltransferase [EC:2.1.1.-]
K23078  menaquinone C8-methyltransferase [EC:2.1.1.350]
K25498  5-methoxybenzimidazole methyltransferase

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